Validation of the Hospital Frailty Score in France
HFRS France
HFRS France
Sponsor study identifier
observational
1,000,000
1 country
1
Study Start
April 1, 2019
Actual (reported)Primary Completion
November 30, 2019
Actual (reported)Study Completion
November 30, 2019
Actual (reported)Older people are increasing users of health care globally. Constraints in bed capacity and resources raise important challenges with regards to management of older people with complex needs, which usually require assertive and holistic assessment. It is important, therefore, to identify aged patients most likely to benefit from such frailty-attuned approaches of care. A previous study using national Hospital Episodes Statistics conducted in the United Kingdom (UK) showed that patients aged over 75 years with characteristics of frailty and at risk of adverse health-care outcomes can be identified using routinely collected data (Gilbert T et al., Lancet 2018). This study lead to the development of the Hospital Frailty Risk Score (HFRS), which is based on International Statistical Classification of Diseases and Related Health Problems 10 (ICD-10) diagnosis codes and has the potential to be used in other countries worldwide, using the ICD-10 coding framework, to identify patients at risk of frailty at the hospital and commissioners levels, as well as for database research purposes. This score has successfully been validated in Canada, Australia and Switzerland. The aim of the present study is to evaluate the ability of the HFRS to predict 30-day in-patient mortality of patients aged 75 years and older admitted to French hospitals as an emergency.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 30, 2019
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1, 2019
Actual (reported)April 4, 2019
Actual (reported)April 5, 2019
Actual (reported)November 30, 2019
Actual (reported)November 30, 2019
Actual (reported)30-day in-patient mortality
The main outcome measure will be 30-day in-patient mortality. Mortality data will be limited to in-hospital mortality, which will be directly available from the PMSI database.
In-patient mortality within 30 days from admission (index hospitalization)
Patients considered will be all patients aged 75 years and older (on the day of the index admission) hospitalized as an emergency (i.e. after visit to ED) between january 2017 and december 2017.
This multi-centric retrospective observational cohort study is conducted using the PMSI. Predictive ability of HFRS estimated on the basis of 3 binary outcomes: 30-day in-patient mortality (main outcome), 30-day emergency and potentially avoidable readmission, length of stay \>15 days. Odds ratios (ORs) and c-statistics calculated and compared to the original UK results in order to validate the use of the HFRS in France. Other secondary objectives include: * Evaluate agreement between HFRS and Charlson or Elixhauser comorbidity indices * Evaluate ability of HFRS combined with comorbidity indices (Charlson on one hand, and Elixhauser on other hand), to predict 30-day in-patient mortality, 30-day emergency and potentially avoidable readmissions, and long length of stay * Identify specific risk associations in France of a high risk of frailty (as assessed by the HFRS) with individual, organizational and territorial factors
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients considered will be all patients aged 75 years and older hospitalized as an emergency over a one year period ranging from January to December 2017. According to a preliminary extraction, we expect to include approximately one million patients.
service de court séjour gériatrique, Hôpital Lyon Sud
Pierre-Bénite, 69495, France
Gilbert T, Cordier Q, Polazzi S, Street A, Conroy S, Duclos A. Combining the Hospital Frailty Risk Score With the Charlson and Elixhauser Multimorbidity Indices to Identify Older Patients at Risk of Poor Outcomes in Acute Care. Med Care. 2024 Feb 1;62(2):117-124. doi: 10.1097/MLR.0000000000001962. Epub 2023 Dec 11.
Gilbert T, Cordier Q, Polazzi S, Bonnefoy M, Keeble E, Street A, Conroy S, Duclos A. External validation of the Hospital Frailty Risk Score in France. Age Ageing. 2022 Jan 6;51(1):afab126. doi: 10.1093/ageing/afab126.
1,000,000 participants (actual enrollment reported by the registry).
First Submitted
April 4, 2019
First Posted
April 5, 2019
Study Start
April 1, 2019
Actual (reported)Home Care Services Screening for Frailty.
Contact the study team to confirm eligibility.
Primary Completion
November 30, 2019
Actual (reported)Study Completion
November 30, 2019
Actual (reported)Last Updated
July 13, 2022
Record last verified: 2022-07
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Source: ClinicalTrials.gov.
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