Air Pollution and COPD Exacerbation

NCT03904875 | Completed

• 1 other identifier: PI2019_843_0008
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

There is an excess of hospitalization rates for acute exacerbation of COPD in Picardy compared to the national data. A first study realized in Picardy has shown a link between air quality and COPD. Nevertheless, the particles type is unknown and according to it, impact on COPD could be different. The investigator goal is to find a correlation between acute exacerbation of COPD consultation rate and daily ultra thin particles in Haut de France. The investigators will correlate the particles composition with daily acute exacerbation of COPD rate. All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie and Lille, and Clinique de l'Europe between 01/01/2020 and 31/12/2020 will be included. For each patient, home and work address will be collected. The duration of 1 year was chosen to take into account seasonal variations. In parallel, a daily report of the rate of ozone, particles (PM2.5 and PM10), dioxide nitrogen but also odours and pollens will be done by ATMO Haut de France.

Conditions

Pollution; Exposure; Chronic Obstructive Pulmonary Disease

Keywords

pollution; Chronic Obstructive Pulmonary Disease; ultrathin particles

Outcome Measures

Primary Outcomes (2)

• daily rate of COPD exacerbation consultation in the emergency room of the 3 centers

  daily rate of COPD exacerbation consultation in the emergency room of the 3 centers

  every day during 12 months

• ultrathin particles quantity in the air

  ultrathin particles quantity will be determined by the air of "Haut de France" by the company ATMO Haut de France.

  every day during 12 months

Secondary Outcomes (1)

• chemical composition ultrathin particles

  every day during 12 months

Interventions

collection of data about each acute exacerbation of COPD OTHER

COPD is chronic obstructive pulmonary disease. Data collected are need of hospitalisation, final diagnosis, home address, work address and air quality data.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie and Lille, and Clinique de l'Europe between 01/01/2020 and 31/12/2020 will be included. Home and work address and spirometric data will be collected. Atmo Hauts-de-France will collect daily data on PM10, PM2,5, NO2 et O3 in Amiens and Lille metropoles. Odours and pollens will be collected too by ATMO Haut de France.

You may qualify if:

• COPD patients with a diagnosis of acute exacerbation of COPD in the emergency room of Amiens and Lille centers
• Adults
• Patients able to express consent
• signed written informed consent form
• covered by national health insurance

You may not qualify if:

• patients non covered by national health insurance
• patients not able to express consent
• minors

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead
• Clinique de l'Europe, Amiens: collaborator
• University Hospital, Lille: collaborator

Study Sites (1)

CHU Amiens

Amiens, 80480, France

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 4, 2019
• First Posted: April 5, 2019
• Study Start: January 1, 2020
• Primary Completion: March 12, 2022
• Study Completion: September 12, 2023
• Last Updated: September 13, 2023

Record last verified: 2023-09

Locations

FR (1)