Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

NCT03897855 | Completed

• 1 other identifier: CH-NIORT-2018-02
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested. This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment. The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Conditions

Post-Traumatic Stress Disorder in Old Age

Outcome Measures

Primary Outcomes (1)

• Inhibition score measured by the Think / No-Think Test

  the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011

  1 month

Study Arms (2)

Patient (TSPT-R)

OTHER

Post Traumatic Stress Disorder

Other: Post Traumatic Stress Disorder

control

EXPERIMENTAL

No Post Traumatic Stress Disorder

Other: Post Traumatic Stress Disorder

Interventions

Post Traumatic Stress Disorder OTHER

The test "Think / No-Think"

Patient (TSPT-R); control

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Regarding the constitution of the group patient (TSPT-R):
• Subjects 65 years of age or older
• Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
• The traumatic event must have taken place at the latest before 65 years
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by research)
• Regarding the constitution of the control group:
• Subjects 65 years of age or older
• No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by the research).

You may not qualify if:

• For both groups:
• Acute or chronic cognitive impairment known
• GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:
• if no diploma
• if certificate of study
• if patent
• if bin or more
• Remove one point at each threshold if age\> 80 years
• Sensory or motor disorder preventing the passing of different tests
• Psychotic disorder
• Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
• Disorder of the use of a moderate or severe substance (except tobacco).
• Patients under guardianship or curatorship.

Sponsors & Collaborators

• Centre Hospitalier de Niort: lead

Study Sites (1)

Centre Hospitalier de Niort

Niort, 79021, France

Location

Study Officials

• Dominique LEGER, Doctor

  Centre Hospitalier de Niort

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2019
• First Posted: April 1, 2019
• Study Start: April 1, 2019
• Primary Completion: April 15, 2019
• Study Completion: March 26, 2021
• Last Updated: July 30, 2021

Record last verified: 2021-07

Locations

FR (1)