NCT03896178

Brief Summary

Firefighters, police, military personnel and pilots are all shown to have a higher incidence of prostate cancer than the general population. A possible explanation for this is that these four groups of employees need regular mandatory health-checkups. If these checkups increase the chances of having a PSA or DRE performed one could expect the workers in question to have a higher probability than the general population of being diagnosed with prostate cancer. If this is the case the four groups should have cancers that are lower grade and have better survival. The investigators wish to examine this by comparing the four groups with a control group made up of all other workers with regards to prognostic factors at the time of diagnosis and survival rates. This will be done by extracting data from the Cancer Registry of Norway, coupled with employment data from Statistics Norway. This study is also a part of a project on cancer in firefighters. If the prostate cancers in firefighters differ significantly from the other three specified groups, this could point to an exposure specific for firefighters, e.g. fire smoke, as an etiologic factor.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
137,536

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 28, 2019

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 29, 2019

Completed
10 months until next milestone

Study Start

First participant enrolled

February 1, 2020

Completed
1 day until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 2, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 2, 2020

Completed
Last Updated

March 1, 2021

Status Verified

February 1, 2021

Enrollment Period

1 day

First QC Date

March 28, 2019

Last Update Submit

February 24, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Cause-specific mortality rate for prostate cancer

    From January 1st 1960 until December 31st 2018

Secondary Outcomes (4)

  • TNM staging

    January 1st 1960 until December 31st 2018

  • Gleason score

    January 1st 1960 until December 31st 2018

  • PSA at time of diagnosis

    January 1st 1960 until December 31st 2018

  • Functional status at time of diagnosis (WHO classification)

    January 1st 1960 until December 31st 2018

Study Arms (5)

Firefighters

Other: None, observational study

Pilots

Other: None, observational study

Police

Other: None, observational study

Military personnel

Other: None, observational study

Controls

Control group matched for geographic location (county), and year of diagnosis. Consisting of all other workers than the four specified groups.

Other: None, observational study

Interventions

None, observational study

ControlsFirefightersMilitary personnelPilotsPolice

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All men registered in the Cancer Registry of Norway with prostate cancer. Analysis of firefighters, pilots, police, military personnel and a matched group of other workers.

You may qualify if:

  • All cases of prostate cancer as registered by the Cancer Registry of Norway

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cancer Registry of Norway

Oslo, 0304, Norway

Location

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Observation

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

MethodsInvestigative Techniques

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
OTHER
Target Duration
60 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD-student

Study Record Dates

First Submitted

March 28, 2019

First Posted

March 29, 2019

Study Start

February 1, 2020

Primary Completion

February 2, 2020

Study Completion

February 2, 2020

Last Updated

March 1, 2021

Record last verified: 2021-02

Data Sharing

IPD Sharing
Will not share

Locations