Prostate Cancer in Firemen: Early Diagnosis Because of Increased Diagnostic Pressure?
Early Detection of Prostate Cancer in Firefighters - a Register-based Study of Prognostic Factors and Survival
1 other identifier
observational
137,536
1 country
1
Brief Summary
Firefighters, police, military personnel and pilots are all shown to have a higher incidence of prostate cancer than the general population. A possible explanation for this is that these four groups of employees need regular mandatory health-checkups. If these checkups increase the chances of having a PSA or DRE performed one could expect the workers in question to have a higher probability than the general population of being diagnosed with prostate cancer. If this is the case the four groups should have cancers that are lower grade and have better survival. The investigators wish to examine this by comparing the four groups with a control group made up of all other workers with regards to prognostic factors at the time of diagnosis and survival rates. This will be done by extracting data from the Cancer Registry of Norway, coupled with employment data from Statistics Norway. This study is also a part of a project on cancer in firefighters. If the prostate cancers in firefighters differ significantly from the other three specified groups, this could point to an exposure specific for firefighters, e.g. fire smoke, as an etiologic factor.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 28, 2019
CompletedFirst Posted
Study publicly available on registry
March 29, 2019
CompletedStudy Start
First participant enrolled
February 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 2, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
February 2, 2020
CompletedMarch 1, 2021
February 1, 2021
1 day
March 28, 2019
February 24, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Cause-specific mortality rate for prostate cancer
From January 1st 1960 until December 31st 2018
Secondary Outcomes (4)
TNM staging
January 1st 1960 until December 31st 2018
Gleason score
January 1st 1960 until December 31st 2018
PSA at time of diagnosis
January 1st 1960 until December 31st 2018
Functional status at time of diagnosis (WHO classification)
January 1st 1960 until December 31st 2018
Study Arms (5)
Firefighters
Pilots
Police
Military personnel
Controls
Control group matched for geographic location (county), and year of diagnosis. Consisting of all other workers than the four specified groups.
Interventions
None, observational study
Eligibility Criteria
All men registered in the Cancer Registry of Norway with prostate cancer. Analysis of firefighters, pilots, police, military personnel and a matched group of other workers.
You may qualify if:
- All cases of prostate cancer as registered by the Cancer Registry of Norway
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Oslo University Hospitallead
- Norwegian Institute of Public Healthcollaborator
- Extrastiftelsencollaborator
- The National Institute of Occupational Healthcollaborator
- Norwegian Confederation of Trade Unionscollaborator
- Fagforbundetcollaborator
- Gjensidige Foundationcollaborator
- Norwegian Cancer Societycollaborator
- Norwegian Firefighters Fight Cancercollaborator
- Norwegian Labour Inspection Authoritycollaborator
Study Sites (1)
Cancer Registry of Norway
Oslo, 0304, Norway
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- OTHER
- Target Duration
- 60 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD-student
Study Record Dates
First Submitted
March 28, 2019
First Posted
March 29, 2019
Study Start
February 1, 2020
Primary Completion
February 2, 2020
Study Completion
February 2, 2020
Last Updated
March 1, 2021
Record last verified: 2021-02
Data Sharing
- IPD Sharing
- Will not share