Transcriptome Assessment After Cardiac Arrest

NCT03895736 | Completed

• 1 other identifier: 2019-A00239-48
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.

Conditions

Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation

Keywords

Transcriptome; messenger ribonucleic acid (mRNA); sequencing; biomarker; cardiac arrest; prognostication; successful resuscitation

Outcome Measures

Primary Outcomes (2)

• Early Transcriptome at hospital admission

  Blood samples will be collected for each patient early after admission at hospital and blood whole transcriptome will be assessed by RNA sequencing

  Day 0

• Pittsburgh Cerebral Performance Category at Day 60

  Pittsburgh Cerebral Performance Category will be evaluated for each patient at day 60

  Day 60

Secondary Outcomes (5)

• Transcriptome at day 1

  Day 1

• Transcriptome at day 3

  Day 3

• Pittsburgh Cerebral Performance Category at Day 28

  day 28

• Number of participants with death at day 28

  day 28

• Number of participants with death at day 60

  day 60

Interventions

blood sampling BIOLOGICAL

Sampling of 15 ml of blood during a blood test at Day 0, Day 1 and Day 3

Also known as: Blood sampling at Day 0, Day 1 and Day 3

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 80 years
• Delay between patients collapse and resumption of spontaneous circulation (ROSC) \< 60 minutes
• Comatose patients ROSC with Glasgow score \< 7
• Patient already registered in the social security system
• Consent of a family member, if able to understand in the emergency context, or attestation of emergency situation with a follow-up information notice

You may not qualify if:

• Cardiac arrest supposed to be provoked by trauma or sepsis

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• National Research Agency, France: collaborator
• University of Paris 5 - Rene Descartes: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• Paris 12 Val de Marne University: collaborator
• Ecole Nationale Vétérinaire d'Alfort: collaborator
• URC-CIC Paris Descartes Necker Cochin: collaborator

Study Sites (1)

Hôpital Cochin, Assistance Publique Hôpitaux de Paris

Paris, 75005, France

Location

MeSH Terms

Conditions

Heart Arrest

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Alain Cariou, Prof.

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

• Renaud Tissier, Prof

  Ecole Nationale Vétérinaire d'Alfort

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2019
• First Posted: March 29, 2019
• Study Start: February 24, 2020
• Primary Completion: February 10, 2022
• Study Completion: February 10, 2022
• Last Updated: November 20, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)