The SwissPrEPared Study
A Multicenter, Observational Cohort to Study the Characteristics of Individuals Asking for Pre-exposure Prophylaxis (PrEP) and the Incidence of HIV and Other Sexually Transmitted Infections: 'The SwissPrEPared Study'
1 other identifier
observational
3,000
1 country
41
Brief Summary
Nested within the SwissPrEPared Program, the "SwissPrEPared Study" - a large, multicentric, nation-wide cohort study - aims to longitudinally follow individuals asking for PrEP prescription over a period of 3 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2019
Longer than P75 for all trials
41 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 14, 2019
CompletedFirst Posted
Study publicly available on registry
March 28, 2019
CompletedStudy Start
First participant enrolled
April 10, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2030
April 6, 2023
March 1, 2023
10.9 years
March 14, 2019
April 3, 2023
Conditions
Outcome Measures
Primary Outcomes (11)
Number of individuals asking for PrEP
Number of individuals asking for PrEP
10 years
Proportion of individuals qualifying for PrEP according to current guidelines
Proportion of individuals qualifying for PrEP according to current guidelines
10 years
PrEP regime used (daily, intermittent, on-demand)
PrEP regime used (daily, intermittent, on-demand)
10 years
Mode of drug supply (pharmacy versus online)
Mode of drug supply (pharmacy versus online)
10 years
Adherence rates to programme
Adherence rates to programme assessed via lost to follow-up and dropouts
10 years
Adherence rates to PrEP
Adherence rates to PrEP measured via self-report questionnaire
10 years
Occurrence of side effects
Occurrence of side effects
10 years
Prevalence of HIV
Prevalence of HIV
10 years
Incidence of HIV
Incidence of HIV
10 years
Prevalence of other STIs (syphilis, hepatitis B, hepatitis C, gonorrhoea, chlamydia, mycoplasma genitalium)
Prevalence of other STIs (syphilis, hepatitis B, hepatitis C, gonorrhoea, chlamydia, mycoplasma genitalium)
10 years
Incidence of other STIs (syphilis, hepatitis B, hepatitis C, gonorrhoea, chlamydia, mycoplasma genitalium)
Incidence of other STIs (syphilis, hepatitis B, hepatitis C, gonorrhoea, chlamydia, mycoplasma genitalium)
10 years
Study Arms (1)
People asking for PrEP
All individuals aged \>18 years asking for PrEP prescription at one of the participating centers will be asked to participate to the SwissPrEPared Study(consecutive ongoing recruitment). Only HIV negative individuals will be deemed eligible.
Eligibility Criteria
All individuals aged \>16 years asking for PrEP prescription at one of the participating centers will be asked to participate to the SwissPrEPared study (consecutive ongoing recruitment). Only HIVnegative individuals will be deemed eligible. Participants for whom PrEP is not indicated or individuals declining PrEP will still be offered to participate in the study.
You may qualify if:
- Participation in the SwissPrEPared program
- Aged ≥16 years
- HIV negative
You may not qualify if:
- Individuals unable to follow program procedures (e.g. language barriers, mental or psychiatric disorders)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Swiss HIV Cohort Studycollaborator
- Federal Office of Public Health, Switzerlandcollaborator
- Positive Council Switzerlandcollaborator
- Cantonal Hospital of St. Gallencollaborator
- University Hospital, University of Berncollaborator
- Cantonal Hosptal, Basellandcollaborator
- University Hospital, Genevacollaborator
- University of Lausanne Hospitalscollaborator
- University Hospital, Basel, Switzerlandcollaborator
Study Sites (41)
Kantonsspital Aarau
Aarau, Canton of Aargau, 5001, Switzerland
Kantonsspital Baden
Baden, Canton of Aargau, 5404, Switzerland
MedCenter Volta
Basel, Canton of Basel-City, 4056, Switzerland
Praxis Hammer
Basel, Canton of Basel-City, 4057, Switzerland
Praxis dr. med. Clara Thierfelder
Basel, Canton of Basel-City, 4058, Switzerland
University Hospital Basel
Basel, Canton of Basel-City, Switzerland
Spitalzentrum Biel - Centre hospitalier Bienne
Biel/Bienne, Canton of Bern, 2501, Switzerland
Spital Thun
Thun, Canton of Bern, 3600, Switzerland
Médecine Interne/Infectiologie FMH
Cottens, Canton of Fribourg, 1741, Switzerland
Hôpital du Jura
Delémont, Canton of Jura, 2800, Switzerland
Kantonsspital Olten
Olten, Canton of Solothurn, 4600, Switzerland
Medical and Therapeutic Centre La Lignière
Gland, Canton of Vaud, 1196, Switzerland
Cabinet Dr. Erika Castro Batänjer
Lausanne, Canton of Vaud, 1003, Switzerland
Cabinet Gare 10
Lausanne, Canton of Vaud, 1003, Switzerland
Cabinet Rumine 35
Lausanne, Canton of Vaud, 1005, Switzerland
Cabinet Rumine 9
Lausanne, Canton of Vaud, 1005, Switzerland
University Hospital Laussane
Lausanne, Canton of Vaud, 1005, Switzerland
Checkpoint Lausanne
Lausanne, Canton of Vaud, Switzerland
Fondation PROFA
Renens VD, Canton of Vaud, 1020, Switzerland
Kantonsspital Winterthur
Winterthur, Canton of Zurich, 8400, Switzerland
Kantonsspital Graubünden
Chur, Kanton Graubünden, 7000, Switzerland
Kantonsspital Münsterlingen
Münsterlingen, Thurgau, 8596, Switzerland
Kantonsspital Ticcino
Lugano, Ticcino, Switzerland
Checkpoint Bern
Bern, 3007, Switzerland
University Hospital Bern
Bern, 3010, Switzerland
Cabinet Dr. Marta Buzzi
Geneva, 1202, Switzerland
Praxis Emmanuelle Boffi
Geneva, 1202, Switzerland
University Hospital Geneva
Geneva, 1205, Switzerland
Cabinet Malagnou 2
Geneva, 1208, Switzerland
Checkpoint Geneva
Geneva, Switzerland
Maihofpraxis
Lucerne, 6004, Switzerland
Réseau Hospitalier Neuchâtelois
Neuchâtel, 2000, Switzerland
Kantonspital St. Gallen
Sankt Gallen, 9007, Switzerland
ARUD
Zurich, 8001, Switzerland
Travel Clinic UZH
Zurich, 8001, Switzerland
Praxis Kalkbreite
Zurich, 8004, Switzerland
Checkpoint Zürich
Zurich, 8005, Switzerland
Dermatologisches Zentrum Zürich AG
Zurich, 8006, Switzerland
Praxisgemeinschaft D29
Zurich, 8008, Switzerland
Stadtspital Triemli
Zurich, 8063, Switzerland
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich
Zurich, 8091, Switzerland
Related Publications (1)
Hovaguimian F, Martin E, Reinacher M, Rasi M, Schmidt AJ, Bernasconi E, Boffi El Amari E, Braun DL, Calmy A, Darling K, Christinet V, Depmeier C, Hauser C, Lauchli S, Notter J, Stoeckle M, Surial B, Vernazza P, Bruggmann P, Tarr P, Haerry D, Bize R, Low N, Lehner A, Boni J, Kouyos RD, Fehr JS, Hampel B. Participation, retention and uptake in a multicentre pre-exposure prophylaxis cohort using online, smartphone-compatible data collection. HIV Med. 2022 Feb;23(2):146-158. doi: 10.1111/hiv.13175. Epub 2021 Oct 3.
PMID: 34605153DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Benjamin Hampel, MD
University of Zurich
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 14, 2019
First Posted
March 28, 2019
Study Start
April 10, 2019
Primary Completion (Estimated)
March 1, 2030
Study Completion (Estimated)
March 1, 2030
Last Updated
April 6, 2023
Record last verified: 2023-03
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
Individual participant data that underlie the results reported in the study protocol (including the statistical plan) will be available after de-identification of participants following article publication. Data will be provided to investigators whose proposed use of the data has been approved by the study team and the Scientific Board of the Swiss HIV Cohort Study. Proposals should be directed to jan.fehr@usz.ch.