NCT03893123

Brief Summary

Firefighters have been shown to be at increased risk for various types of cancer, including prostate cancer. This study will try to explore possible reasons for this increase in risk. A study group at the Cancer Registry of Norway is creating a cohort of Norwegian firemen employed from 1960 onwards. A job exposure matrix (JEM) is also being constructed, examining different types of exposure to potentially cancer-inducing agents and activities, and how these have changed historically. Examples include exposure to fire-smoke, shiftwork, diesel exhaust and regular health check-ups. By linking the cohort with data from the Cancer Registry of Norway and the JEM the investigators can examine which exposure assessments, if any, are related to an increased risk of prostate cancer.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
4,500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2018

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2018

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

March 25, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 28, 2019

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2020

Completed
1.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2021

Completed
Last Updated

March 4, 2020

Status Verified

March 1, 2020

Enrollment Period

2.1 years

First QC Date

March 25, 2019

Last Update Submit

March 3, 2020

Conditions

Prostatic Cancer

Outcome Measures

Primary Outcomes (1)

  • Incidence of prostate cancer

    As reported to the Cancer Registry of Norway

    From January 1st 1960 until December 31st 2018

Study Arms (1)

Firefighters

Other: Observational study, prostate cancer is outcome of interest

Interventions

Observational study, prostate cancer is outcome of interestOTHER

Observational study

Firefighters

Eligibility Criteria

Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Norwegian males

You may qualify if:

  • Work as firefighter as recorded by the participating fire stations

You may not qualify if:

  • Any other occupation, including chimney sweepers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cancer Registry of Norway

Oslo, 0304, Norway

Location

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Observation

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

MethodsInvestigative Techniques

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD-student

Study Record Dates

First Submitted

March 25, 2019

First Posted

March 28, 2019

Study Start

January 1, 2018

Primary Completion

February 1, 2020

Study Completion

December 1, 2021

Last Updated

March 4, 2020

Record last verified: 2020-03

Data Sharing

IPD Sharing
Will not share

Locations

NO(1)