Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy
1 other identifier
observational
50
0 countries
N/A
Brief Summary
- 1.To detect IKZF-1 deletion mutations in patients with ALL.
- 2.To study the impact of IKZF-1 deletion mutation on therapy of ALL.
- 3.To study the correlation between IKZF-1 deletion mutations and BCR-ABL.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2019
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 28, 2019
CompletedFirst Posted
Study publicly available on registry
March 26, 2019
CompletedStudy Start
First participant enrolled
April 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2020
CompletedMarch 26, 2019
March 1, 2019
1 year
February 28, 2019
March 25, 2019
Conditions
Outcome Measures
Primary Outcomes (2)
detection of IKZF-1 deletion mutations in patients with ALL.
detection of IKZF1 deletion mutation by fluorescent inset hybridization and by PCR.
baseline
Detection of BCR-ABL translocation.
by PCR
baseline
Study Arms (2)
group 1
group of ALL patients with IKZF1 deletion mutation.
group 2
group of ALL patients with no detected mutation
Eligibility Criteria
patients newly diagnosed with acute lymphoblastic leukemia age ranged from 1 year to 70 years.
You may qualify if:
- Patients with acute lymphoblastic leukemia.
You may not qualify if:
- patients with any other hematological malignancies.
- patients receiving chemotherapy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
February 28, 2019
First Posted
March 26, 2019
Study Start
April 1, 2019
Primary Completion
April 1, 2020
Study Completion
May 1, 2020
Last Updated
March 26, 2019
Record last verified: 2019-03