Perthes Disease in Norway

NCT03885960 | Active Not Recruiting

• 1 other identifier: 2018/1924
• Study Type: observational
• Target: 216
• Locations: 1 country
• Sites: 1

Brief Summary

Calvé-Legg-Perthes disease (CLP) is a hip disease in children whose femoral head becomes completely or partially necrotic. The disease is most common in five-six years of age. The femoral head is gradually deformed during the active stages of the disease (5-7 years). By healing, the hip joint shape will vary from an approximately normal joint to pronounced changes, the hip joint will be irregular. Such a hip joint is available for osteoarthritis. The purpose of this study is to map the function of the hip, the patient's quality of life and especially the risk factors that affect the outcome of the previous CLP. A nationwide prospective study of CLP was conducted between 1996 and 2000. All children with newly diagnosed Perthes disease (425) were registered. The current study will follow up all these patients with an average follow-up of 20 years. Radiological endpoints are evidence of hip osteoarthritis. Patient-reported outcomes (PROMS) should illuminate the function of the hip and quality of life.

Conditions

Legg Calve Perthes Disease

Keywords

Hip; function; quality of life; osteoarthritis; Perthes; LCPD

Outcome Measures

Primary Outcomes (2)

• Hip osteoarthritis

  radiographic measurement of weight bearing zone

  an average of 20 years follow-up

• Hip function

  PROMS HOOS

  an average of 20 years follow-up

Secondary Outcomes (3)

• Hip ROM

  an average of 20 years follow-up

• Gluteal muscle strength

  an average of 20 years follow-up

• Hip strength

  an average of 20 years follow-up

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients which have been diagnosed with Perthes disease in between 1996 and 2000 in Norway were registered and follow at least 5 years after diagnosis. All hospitals throughout Norway with orthopaedic service were included in the registration. Our study is a 20 years follow-up of the original study.

You may qualify if:

• \- Subject was diagnosed with Perthes disease between 1996 and 2000 in Norway

You may not qualify if:

• Death upon follow up
• Other skeletal dysplasia
• Patient not able to give consent,

Sponsors & Collaborators

• Oslo University Hospital: lead
• Sophies Minde Ortopedi: collaborator

Study Sites (1)

Oslo University Hospital - Rikshospitalet

Oslo, Sognsvannsveien 20, 0372, Norway

Location

MeSH Terms

Conditions

Legg-Calve-Perthes Disease; Osteoarthritis

Condition Hierarchy (Ancestors)

Femur Head Necrosis; Osteonecrosis; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases; Rheumatic Diseases

Study Officials

• Stefan Huhnstock, Phd

  Oslo University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 9, 2019
• First Posted: March 22, 2019
• Study Start: November 1, 2018
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: March 18, 2025

Record last verified: 2025-03

Locations

NO (1)