NCT03885375

Brief Summary

Cardiac involvements in autoimmune diseases (AD) is common but underestimated and an early detection remains a clinical challenge for lacking of efficient imaging methods. The objective of the study was to investigate LV myocardial abnormalities in AD patients by multimodal cardiac imaging, including speckle-tracking echocardiology (STE), cardiac magnetic resonance imaging (CMRI) and positron emission tomography (PET).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2018

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2018

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

January 2, 2019

Completed
3 months until next milestone

First Posted

Study publicly available on registry

March 21, 2019

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2020

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2020

Completed
Last Updated

March 21, 2019

Status Verified

September 1, 2018

Enrollment Period

2 years

First QC Date

January 2, 2019

Last Update Submit

March 19, 2019

Conditions

Outcome Measures

Primary Outcomes (3)

  • Change in deformational parameters in echocardiography during follow-up period

    global longitudinal strain (%), circumferential strain (%) and radial strain (%) measured by STE in autoimmune diseases

    6 months - 1 year - 2 years

  • Progression of myocardial fibrosis and edema during follow-up period

    Late Gadolinium Enhanced, T1 mapping and T2 mapping tested by CMRI

    1 year - 2 years

  • Change in myocardial perfusion during follow-up period

    SUVmax examined by PET

    1 year - 2 years

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patient is diagnosed with autoimmune diseases, including systemic lupus erythematosus (SLE), vasculitis, dermatomyositis, sjogren's syndrome, scleroderma, rheumatoid arthritis and IgG4 associated disease. Patient is capable of complying with study procedures.

You may qualify if:

  • Patient is diagnosed with autoimmune diseases, including systemic lupus erythematosus (SLE), vasculitis, dermatomyositis, sjogren's syndrome, scleroderma, rheumatoid arthritis and IgG4 associated disease.
  • Patient is capable of complying with study procedures

You may not qualify if:

  • Patient is pregnant or nursing
  • Patient is complicated with congenital heart disease
  • Patient had cardiac surgery before
  • Patient is complicated with serious infections
  • Patient is complicated with organ failure
  • Patient is complicated with tumors
  • Patient is diagnosed indefinitely
  • Patient has been involved in other clinical trial

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Peking Union Medical College Hostipal

Beijing, Beijing Municipality, 100010, China

RECRUITING

MeSH Terms

Conditions

Autoimmune Diseases

Condition Hierarchy (Ancestors)

Immune System Diseases

Central Study Contacts

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 2, 2019

First Posted

March 21, 2019

Study Start

April 1, 2018

Primary Completion

April 1, 2020

Study Completion

April 30, 2020

Last Updated

March 21, 2019

Record last verified: 2018-09

Locations