Incidence and Risk of Influenza in Myasthenic Patients

NCT03884777 | Completed DMC

• 1 other identifier: CIC1429
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Upper respiratory infection , including influenza, may exacerbate the symptoms of myasthenia gravis (MG), which is an autoimmune disease that causes muscle weakness and, in some cases, can precipitate a myasthenic crisis In the present study, we investigated the incidence and risk factors of influenza infection on in myasthenia gravis patients.

Conditions

Myasthenic Crisis; Upper Respiratory Infection

Keywords

Influenza A virus; myasthenia gravis; neurocritical care clinical; neuromuscular disease

Outcome Measures

Primary Outcomes (1)

• Incidence of influenza in myasthenic patient in crisis

  Number of influenza cases in myasthenic patients

  between January 1, 2009 and December 31, 2017.

Secondary Outcomes (1)

• Risk factors for poor outcomes

  between January 1, 2009 and December 31, 2017.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inclusion of 416 cases of myasthenic patients treated in the intensive care unit of Garches Hospital between January 1, 2009 and December 31, 2017.

You may qualify if:

• Men or women over the age of 18.
• Myasthenic patients hospitalized in intensive care.
• Patients with confirmed influenza infection

You may not qualify if:

• Age \<18 years,
• Other neuromuscular diseases,
• Patient opposing the use of his data

Sponsors & Collaborators

• Centre d'Investigation Clinique et Technologique 805: lead

Related Publications (4)

• Petrova VN, Russell CA. The evolution of seasonal influenza viruses. Nat Rev Microbiol. 2018 Jan;16(1):60. doi: 10.1038/nrmicro.2017.146. Epub 2017 Nov 7.

  PMID: 29109554 RESULT

• Tackenberg B, Schneider M, Blaes F, Eienbroker C, Schade-Brittinger C, Wellek A, Deschauer M, Eickmann M, Klenk HD, Muller HH, Sommer N. Acetylcholine Receptor Antibody Titers and Clinical Course after Influenza Vaccination in Patients with Myasthenia Gravis: A Double-Blind Randomized Controlled Trial (ProPATIent-Trial). EBioMedicine. 2018 Feb;28:143-150. doi: 10.1016/j.ebiom.2018.01.007. Epub 2018 Jan 10.

  PMID: 29337134 RESULT

• Friman G, Schiller HH, Schwartz M. Distubed neuromuscular transmission in viral infections. Scand J Infect Dis. 1977;9(2):99-103. doi: 10.3109/inf.1977.9.issue-2.08.

  PMID: 197596 RESULT

• Rosciszewska D, Bluszcz M, Kurek H. [Antibodies for DNA and RNA viruses in the serum of myasthenia patients. Preliminary report]. Neurol Neurochir Pol. 1981 Sep-Dec;15(5-6):541-4. Polish.

  PMID: 6281675 RESULT

MeSH Terms

Conditions

Respiratory Tract Infections; Myasthenia Gravis; Neuromuscular Diseases

Condition Hierarchy (Ancestors)

Infections; Respiratory Tract Diseases; Paraneoplastic Syndromes, Nervous System; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Paraneoplastic Syndromes; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Neurodegenerative Diseases; Neuromuscular Junction Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Rania BOUNAB, Dr

  Raymond Poincaré Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 16, 2019
• First Posted: March 21, 2019
• Study Start: January 1, 2009
• Primary Completion: December 31, 2017
• Study Completion: December 31, 2017
• Last Updated: March 21, 2019

Record last verified: 2017-12