Effects of Acute Exercise on Pain and Human Movement

NCT03882333 | Completed

• 1 other identifier: Dalarna University 2017-00177
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research project is to evaluate the effect of an acute exercise intervention on pain intensity and movement control. It also aims to investigate potential differences in movement con-trol between patients with chronic musculoskeletal pain compared to healthy controls.

Conditions

Chronic Musculoskeletal Disease; Chronic Pain, Widespread

Keywords

Chronic musculoskeletal pain; Acute exercise; Movement control; Muscle activity

Outcome Measures

Primary Outcomes (2)

• Kinematic measures of human movement during functional gait sequences

  Objective measures of movement control using sophisticated wearable sensors (accelerometer-based APDM-sensors applied at participants wrists, ankles, chest and head) during walking in 1) self-selected normal gait speed, 2) a brisk gait speed, 3) self-selected normal gait speed with a concurrent cognitive task (1-back test: participants listens to a recording of a voice that presents random series of digits between 1 to 9 with two seconds apart. The participants will be instructed to respond as quickly and accurately as possible, repeating the digit before the last one in the sequence.). Lumbar trunk rotations (degrees) will specifically be evaluated while many other kinematic variables (walking speed, step length, step width etc) will be analyzed with factor analyz-es to reduce data variables to relevant data domains, such as gait stability. Data will be aggregated as means and variances.

  30 minutes (before and after the acute exercise intervention)

• Muscle activity

  Evaluation of back muscle activity using electromyographics (EMG) during walking as in outcome 1, i.e. in 1) self-selected normal gait speed, 2) a brisk gait speed, 3) self-selected normal gait speed with a concurrent cognitive task (1-back test). Participants will be instrumented with surface-EMG (Delsys Incorporated, Massachusetts) electrodes applied bilateral at participants back and neck muscles. Back and neck spatial and temporal muscle activity (EMG amplitudes) representing repeated gait cycles will be aggregated to one cycle; factor analyzes may be applied to reduce data variables to relevant data domains. Data will be presented as means and variances.

  30 minutes (before and after the acute exercise intervention)

Secondary Outcomes (1)

• Self-rated pain using the Visual Analogue Scale (VAS scale).

  30 minutes (before and after the acute exercise intervention)

Study Arms (2)

Acute exercise

EXPERIMENTAL

Acute exercise (bicycle at stationary cycle).

Other: Acute exercise

Rest

NO INTERVENTION

Rest (lying down or sitting in a chair) for 30 minutes, i.e. same time duration as in experimental arm.

Interventions

Acute exercise OTHER

30 min acute exercise (bicycle at stationary cycle)

Acute exercise

Eligibility Criteria

• Age: 18 Years - 67 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women, age 18-67 years,
• good ability to understand written and verbal information and instruction given in Swedish,
• chronic (\>3 months) musculoskeletal pain or chronic widespread pain.
• Men and women, age 18-67 years,
• good ability to understand written and verbal information and instruction given in Swedish.

You may not qualify if:

• For participants with chronic pain
• chronic pain caused by malignancies or systemic diseases, other physical conditions that affects functional abilities and implies use of walking aid in-door,
• pregnancy after week 12, childbirth within the last 3 months or
• spinal surgery.
• For healthy controls:
• chronic (\>3 months) or acute pain of any cause,
• other physical conditions that affects functional abilities, and implies use of walking aids in-door,
• pregnancy after week 12, childbirth in the last 3 months or
• spinal surgery.

Sponsors & Collaborators

• Dalarna University: lead
• Dalarna County Council, Sweden: collaborator
• Swedish Council for Working Life and Social Research: collaborator
• Karolinska Institutet: collaborator
• Swedish Armed Forces: collaborator

Study Sites (1)

Dalarna University (LIVI lab)

Falun, Dalarna County, 79131, Sweden

Location

Related Publications (10)

• Boecker H, Sprenger T, Spilker ME, Henriksen G, Koppenhoefer M, Wagner KJ, Valet M, Berthele A, Tolle TR. The runner's high: opioidergic mechanisms in the human brain. Cereb Cortex. 2008 Nov;18(11):2523-31. doi: 10.1093/cercor/bhn013. Epub 2008 Feb 21.

  PMID: 18296435 BACKGROUND

• Brumagne S, Janssens L, Knapen S, Claeys K, Suuden-Johanson E. Persons with recurrent low back pain exhibit a rigid postural control strategy. Eur Spine J. 2008 Sep;17(9):1177-84. doi: 10.1007/s00586-008-0709-7. Epub 2008 Jul 2.

  PMID: 18594876 BACKGROUND

• van den Hoorn W, Bruijn SM, Meijer OG, Hodges PW, van Dieen JH. Mechanical coupling between transverse plane pelvis and thorax rotations during gait is higher in people with low back pain. J Biomech. 2012 Jan 10;45(2):342-7. doi: 10.1016/j.jbiomech.2011.10.024. Epub 2011 Nov 10.

  PMID: 22078275 BACKGROUND

• Seay JF, Van Emmerik RE, Hamill J. Influence of low back pain status on pelvis-trunk coordination during walking and running. Spine (Phila Pa 1976). 2011 Jul 15;36(16):E1070-9. doi: 10.1097/BRS.0b013e3182015f7c.

  PMID: 21304421 BACKGROUND

• Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010 Mar 23;340:c332. doi: 10.1136/bmj.c332.

  PMID: 20332509 BACKGROUND

• Darnall BD, Sturgeon JA, Cook KF, Taub CJ, Roy A, Burns JW, Sullivan M, Mackey SC. Development and Validation of a Daily Pain Catastrophizing Scale. J Pain. 2017 Sep;18(9):1139-1149. doi: 10.1016/j.jpain.2017.05.003. Epub 2017 May 19.

  PMID: 28528981 BACKGROUND

• Bergstrom G, Jensen IB, Bodin L, Linton SJ, Nygren AL, Carlsson SG. Reliability and factor structure of the Multidimensional Pain Inventory--Swedish Language Version (MPI-S). Pain. 1998 Mar;75(1):101-110. doi: 10.1016/S0304-3959(97)00210-8.

  PMID: 9539679 BACKGROUND

• Tseli E, Boersma K, Stalnacke BM, Enthoven P, Gerdle B, Ang BO, Grooten WJA. Prognostic Factors for Physical Functioning After Multidisciplinary Rehabilitation in Patients With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. Clin J Pain. 2019 Feb;35(2):148-173. doi: 10.1097/AJP.0000000000000669.

  PMID: 30371517 BACKGROUND

• Molander P, Dong HJ, Ang B, Enthoven P, Gerdle B. The role of pain in chronic pain patients' perception of health-related quality of life: a cross-sectional SQRP study of 40,000 patients. Scand J Pain. 2018 Jul 26;18(3):417-429. doi: 10.1515/sjpain-2018-0003.

  PMID: 29794267 BACKGROUND

• Westergren J, Sjoberg V, Vixner L, Nyberg RG, Moulaee Conradsson D, Monnier A, LoMartire R, Enthoven P, Ang BO. Acute exercise as active inference in chronic musculoskeletal pain, effects on gait kinematics and muscular activity in patients and healthy participants: a study protocol for a randomised controlled laboratory trial. BMJ Open. 2023 May 31;13(5):e069747. doi: 10.1136/bmjopen-2022-069747.

  PMID: 37258077 DERIVED

MeSH Terms

Conditions

Chronic Pain

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Björn BA Äng, Assoc. Prof.

  Dalarna University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: A randomised controlled study in patients with chronic pain and healthy controls

Study Record Dates

• First Submitted: December 12, 2018
• First Posted: March 20, 2019
• Study Start: December 12, 2018
• Primary Completion: June 30, 2021
• Study Completion: June 30, 2021
• Last Updated: September 9, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)