Split Renal Function Using 99mTc-DTPA Versus 99mTc-DMSA in Kidney Patients of Wide Age Ranges.

NCT03879005 | Unknown

• 1 other identifier: SRF using DTPA Vs DMSA
• Study Type: interventional
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate split renal function using Tc-99m DTPA versus Tc-99m DMSA.

Conditions

The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients

Outcome Measures

Primary Outcomes (1)

• Split renal function using 99mTc-DTPA versus 99mTc-DMSA in kidney patients of wide age ranges.

  To emphasize that split renal function calculated with Tc-99m DTPA is as reliable as Tc-99m DMSA

  one year

Study Arms (1)

Renal scintigraphy

OTHER

5 mci of 99mTc-DTPA or 99mTc-DMSA is injected once IV. Dose is adjusted according to age and weight.

Other: renal scintigraphy

Interventions

renal scintigraphy OTHER

99mTc-DTPA Scintigraphy Five mci of 99mTc-DTPA will be injected by IV route together with diuretic. Dose will be adjusted according to the age and weight of the patients. A total of 20 min dynamic imaging followed by calculation of GFR and SRF according to the built-in processing protocol Gate's method. 99mTc-DMSA scintigraphy Five mci of 99mTc- DMSA will be injected by IV route with adjustment according to age and weight. Static images will be acquired in the posterior, anterior, andposterior oblique projections for 60 s each.

Also known as: 99mTc-DTPA & 99mTc-DMSA renal scintigraphy

Renal scintigraphy

Eligibility Criteria

• Age: 2 Months - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Kidney patients of wide age ranges.
• Patients with renal disorders who referred for DMSA and DTPA split renal function.
• Patients able to sleep in a fixed position for 20 minutes.

You may not qualify if:

• Children unable to sit calm without movement during imaging.
• Severely ill patients.
• Patients with allergy to one or more of material method.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Ardela Diaz E, Miguel Martinez B, Gutierrez Duenas JM, Diez Pascual R, Garcia Arcal D, Dominguez Vallejo FJ. [Comparative study of differential renal function by DMSA and MAG-3 in congenital unilateral uropathies]. Cir Pediatr. 2002 Jul;15(3):118-21. Spanish.

  PMID: 12601986 RESULT

• Cao X, Xu X, Grant FD, Treves ST. Estimation of Split Renal Function With 99mTc-DMSA SPECT: Comparison Between 3D Volumetric Assessment and 2D Coronal Projection Imaging. AJR Am J Roentgenol. 2016 Dec;207(6):1324-1328. doi: 10.2214/AJR.16.16307. Epub 2016 Sep 13.

  PMID: 27623376 RESULT

• Celik T, Yalcin H, Gunay EC, Ozen A, Ozer C. Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children. World J Nucl Med. 2014 Sep;13(3):149-53. doi: 10.4103/1450-1147.144812.

  PMID: 25538484 RESULT

• Lee WG, Kim JH, Kim JM, Shim KM, Kang SS, Chae HI, Choi SH. Renal uptakes of 99mTc-MAG3, 99mTc-DTPA, and 99mTc-DMSA in rabbits with unilateral ureteral obstruction. In Vivo. 2010 Mar-Apr;24(2):137-9.

  PMID: 20363984 RESULT

Study Officials

• Mohamed AH Mekkawy, professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Marwa F Abd El Hay

CONTACT

0102291658; f.marwa1992@gmail.com

Waleed A Diab, MD

CONTACT

01004242213; Drwaleedin2000@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: March 8, 2019
• First Posted: March 18, 2019
• Study Start: April 1, 2019
• Primary Completion: September 1, 2019
• Study Completion: October 1, 2019
• Last Updated: March 21, 2019

Record last verified: 2019-03