Combined Oral Vitamin D and UVB Versus UVB Alone in Treatment of Psoriasis Vulgaris

NCT03874975 | Unknown Early Phase 1

• 1 other identifier: vit D and UVB in psoriasis
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare the results of vitamin D plus UVB in treatment of psoriasis vulgaris with the results of UVB alone to study the relation between serum vitamin D and PASI score before and after treatment.

Conditions

Psoriasis Vulgaris

Outcome Measures

Primary Outcomes (1)

• measure serum vitamin D before and after treatment in psoriatic patients

  A 3ml blood sample will be collected from the patients, then allowed to clot for 10 minutes and then centrifuged . Group 1: 20 patients under oral vitamin D therapy ( oral alpha one for 3 months o.25 microgram / day ) in combination with narrow band UVB settings (twice/week) Group 2 : 20 patients under narrow band UVB therapy only . c) We evaluate psoriatic patient by PASI score before and after treatment : ) measurment vitamin D level before and after treatment.

  1 year

Secondary Outcomes (1)

• We evaluate psoriatic patient by PASI score before and after treatment :

  1 year

Interventions

oral vitamin D DRUG

vitamin D and UVB versus UVB alone in psoriatic patients and evaluate patients by PASI score before and after treatment and measure serum vitamin D before and after treatment

Also known as: narrow band UVB

Eligibility Criteria

• Age: 10 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• : patients from 10 to 60 diagnosed to have psoriasis vulgaris

You may not qualify if:

• concomitant chronic inflammatory disease or malignancy.
• pregnant and lactating women.
• renal dysfunction.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Interventions

Vitamin D

Intervention Hierarchy (Ancestors)

Secosteroids; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Central Study Contacts

meryhan abdelazeem, master

CONTACT

01204425625; ashrafmeryhan7@gmail.com

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal Investigator

Model Details: 40 patients divided into two groups : group 1 :20 patients underoral vitamin D and UVB group 2 : 20 patients under uvb alone in psoriatic patients

Study Record Dates

• First Submitted: March 6, 2019
• First Posted: March 14, 2019
• Study Start: April 1, 2019
• Primary Completion: April 1, 2019
• Study Completion: April 1, 2020
• Last Updated: March 14, 2019

Record last verified: 2019-03