Study of Endocrine-Related Conditions and Physiology

NCT03867448 | Recruiting

• 2 other identifiers: 19006619-DK-0066
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Endocrine disorders involve changes to glands that produce hormones. Hormones are released by these glands into the blood so they can direct the function of other tissues in the body. Researchers want to study people who may have endocrine disorders. They want to learn more about the conditions that affect endocrine glands. Objective: To study adults with a variety of endocrine disorders for research and physician education. Eligibility: Adults ages 18 and older who have an endocrine or metabolic-related disorder Healthy volunteers 18 and older Design: Participants will be screened with a review of their medical records. Participants will have a physical exam and medical history. The length of the study and the schedule will vary by participant. Tests may include: Blood and urine tests Stool and saliva samples Imaging studies: Participants will lie on a table while a machine takes pictures of the body. They may be injected with a substance to make their organs more visible in the pictures. Tests of endocrine tissue function Consultation with other specialists Sleep study Medical photographs Participants may be treated for their endocrine disorder. This could include: Surgery. If tissue is removed during surgery, it may be studied. Radiation Medicine Participants may have genetic testing. This will be done with a small amount of blood, cells from a cheek swab, or saliva. Sponsoring Institution: National Institute of Digestive, Diabetes and Kidney Disease

Conditions

Endocrine Disease

Keywords

Adrenal Gland; Pituitary; Natural History

Outcome Measures

Primary Outcomes (1)

• Diagnosis/Treatment

  determination of diagnosis and/or treatment of an endocrine disorder

  variable

Study Arms (2)

Adults with Endocrine Disorder

Adults referred to NIH with possible endocrine conditions

Adults with hyperaldosteronism

Adults referred to NIH or studied at NIH and determined to have hyperaldosteronism

Device: Creation of side holes in catheters for adrenal vein sampling

Interventions

Creation of side holes in catheters for adrenal vein sampling DEVICE

one or two side-holes will be created by the interventional radiologist to facilitate adrenal vein sampling

Adults with hyperaldosteronism

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

any adult with a potential endocrine disorder; the types of disorders may vary to ensure that there is an adequate case mix of diagnoses for the training program.

You may qualify if:

• In order to be eligible to participate in this study, an individual must meet all the following criteria:
• Adult men and women age 18 years or older.
• Known or suspected endocrine disorders requiring clinical screening, management and/or treatment and follow-up.
• Stated willingness to comply with all study procedures and availability for the duration of the study

You may not qualify if:

• Unstable participants and participants with severe organ failure, or those with a condition or medical treatment that may affect/limit the endocrine work-up and exhaust Clinical Center, IETP resources will be excluded if appropriate.
• Inability of a subject to adhere to a proposed schedule of visits.
• Inability to provide informed consent.

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

RECRUITING

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Conditions

Endocrine System Diseases; Pituitary Diseases

Interventions

Catheters

Condition Hierarchy (Ancestors)

Hypothalamic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Equipment and Supplies

Study Officials

• Lynnette K Nieman, M.D.

  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raven N McGlotten, R.N.

CONTACT

(301) 827-0190; mcglottenr@mail.nih.gov

Lynnette K Nieman, M.D.

CONTACT

(301) 496-8935; niemanl@mail.nih.gov

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2019
• First Posted: March 8, 2019
• Study Start: March 27, 2019
• Primary Completion (Estimated): January 1, 2036
• Study Completion (Estimated): January 1, 2036
• Last Updated: April 24, 2026

Record last verified: 2026-03-31

Locations

US (1)