Myocardial Perfusion Imaging in Liver Transplantation Candidates
ExSPECT
Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates Study
1 other identifier
observational
403
0 countries
N/A
Brief Summary
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear. Although consensus based guidelines support noninvasive stress testing prior to orthotopic liver transplantation (OLT), no prospective studies are available to inform the clinician on perioperative risk stratification. This observational cohort study was designed to determine the prognostic utility of single photon emission computed tomography (SPECT) imaging in OLT candidates.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2007
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2007
CompletedFirst Submitted
Initial submission to the registry
March 4, 2019
CompletedFirst Posted
Study publicly available on registry
March 6, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2019
CompletedJune 19, 2019
June 1, 2019
11.8 years
March 4, 2019
June 16, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Cardiovascular mortality
10 years
Secondary Outcomes (2)
Major adverse cardiovascular event
10 years
All-cause mortality
10 years
Study Arms (1)
Orthotopic liver transplantation candidates
No intervention, imaging test and risk stratification as part of routine clinical care.
Interventions
Eligibility Criteria
Consecutive patients with end-stage liver disease were identified after referral to the Queen Elizabeth Hospital Birmingham for CV risk stratification as part of a pre-transplant screening work-up. Subjects were referred for non-invasive CV risk assessment based on the above criteria.
You may qualify if:
- Liver transplantation candidates with one or more of the following:
- inability to perform \>4 METs by history
- insulin-treated diabetes mellitus
- serum creatinine \>152μmol/l
- history of MI, PCI or CABG
- stable angina
- cerebrovascular disease
- peripheral vascular disease
You may not qualify if:
- Age \< 18 years
- Pregnancy
- Contraindication to liver transplantation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Moody WE, Holloway B, Arumugam P, Gill S, Wahid YS, Boivin CM, Thomson LE, Berman DS, Armstrong MJ, Ferguson J, Steeds RP. Prognostic value of coronary risk factors, exercise capacity and single photon emission computed tomography in liver transplantation candidates: A 5-year follow-up study. J Nucl Cardiol. 2021 Dec;28(6):2876-2891. doi: 10.1007/s12350-020-02126-z. Epub 2020 May 11.
PMID: 32394403DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Richard P Steeds, MD
University Hospital Birmingham NHS Foundation Trust
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Consultant Cardiologist with a Specialist Interest in Cardiac Imaging
Study Record Dates
First Submitted
March 4, 2019
First Posted
March 6, 2019
Study Start
September 1, 2007
Primary Completion
June 1, 2019
Study Completion
June 1, 2019
Last Updated
June 19, 2019
Record last verified: 2019-06
Data Sharing
- IPD Sharing
- Will not share