Myocardial Perfusion Imaging in Liver Transplantation Candidates
ExSPECT
Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates Study
ExSPECT
Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates Study
Sponsor study identifier
observational
403
0 countries
N/A
Study Start
September 2007
Actual (reported)Primary Completion
June 2019
Actual (reported)Study Completion
June 2019
Actual (reported)The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear. Although consensus based guidelines support noninvasive stress testing prior to orthotopic liver transplantation (OLT), no prospective studies are available to inform the clinician on perioperative risk stratification. This observational cohort study was designed to determine the prognostic utility of single photon emission computed tomography (SPECT) imaging in OLT candidates.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2019
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 2007
Actual (reported)March 4, 2019
Actual (reported)March 6, 2019
Actual (reported)June 2019
Actual (reported)June 2019
Actual (reported)Cardiovascular mortality
10 years
Major adverse cardiovascular event
10 years
All-cause mortality
10 years
No intervention, imaging test and risk stratification as part of routine clinical care.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Consecutive patients with end-stage liver disease were identified after referral to the Queen Elizabeth Hospital Birmingham for CV risk stratification as part of a pre-transplant screening work-up. Subjects were referred for non-invasive CV risk assessment based on the above criteria.
Moody WE, Holloway B, Arumugam P, Gill S, Wahid YS, Boivin CM, Thomson LE, Berman DS, Armstrong MJ, Ferguson J, Steeds RP. Prognostic value of coronary risk factors, exercise capacity and single photon emission computed tomography in liver transplantation candidates: A 5-year follow-up study. J Nucl Cardiol. 2021 Dec;28(6):2876-2891. doi: 10.1007/s12350-020-02126-z. Epub 2020 May 11.
Richard P Steeds, MD
University Hospital Birmingham NHS Foundation Trust
403 participants (actual enrollment reported by the registry).
First Submitted
March 4, 2019
First Posted
March 6, 2019
Study Start
September 2007
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
June 2019
Actual (reported)Study Completion
June 2019
Actual (reported)Last Updated
June 19, 2019
Record last verified: 2019-06
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Source: ClinicalTrials.gov.
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