Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort

NCT03864380 | Completed

• 1 other identifier: MMT_2018_10
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization. The eye allows in vivo visualization of micro-vascularisation and is considered as an excellent marker of general vascular condition. The marathon is an intense and prolonged exercise (running 42.195 km) in aerobic environment. Thus the investigators propose to study the vascular parameters of the retina, before and after this physical exercise. This will allow : 1) to collect information on the physiology of the retinal vascularization to prolonged effort, 2) to detect any retinal damage (haemorrhages, edema, occlusion ...), not known to date. The results may highlight vascular effects related to retinal hypoxia (venous tortuosity, haemorrhage, venous occlusion, hypoxic edema). Furthermore the results may urge prevention in this sport more and more democratized. the investigators hypothesized that prolonged physical exercice causes a change in retinal vascularization.

Conditions

Retinal Vascular Disorder; Sport Injury

Keywords

Retinal Vascularization; Intense effort; OCT-A

Outcome Measures

Primary Outcomes (1)

• Density of retinal vascular plexuses

  Percentage, Measurement with OCT-A

  up to 1 hour

Study Arms (1)

Person running a marathon

Exams performed before (1 month maximum) and after the marathon (1 hour maximum) : Color retinography Optical Coherence Tomography - Angiography (OCT-A) Blood pressure measurement

Diagnostic Test: Color retinography; Diagnostic Test: OCT-A; Diagnostic Test: Blood pressure measurement

Interventions

Color retinography DIAGNOSTIC_TEST

Non mydriatic color retinography within 1 month before and within 1 hour after the marathon

Person running a marathon

OCT-A DIAGNOSTIC_TEST

Optical Coherence Tomography - Angiography within 1 month before and within 1 hour after the marathon

Person running a marathon

Blood pressure measurement DIAGNOSTIC_TEST

Blood pressure measurement within 1 month before and within 1 hour after the marathon

Person running a marathon

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Person running a marathon

You may qualify if:

• Person registered at the 2019 Paris Marathon

You may not qualify if:

• Ophthalmological disorders making access to the fundus impossible for both eyes

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation A de Rothschild

Paris, 75019, France

Location

Related Publications (1)

• Mauget-Faysse M, Arej N, Paternoster M, Zuber K, Derrien S, Thevenin S, Alonso AS, Salviat F, Lafolie J, Vasseur V. Retinal and choroidal blood flow variations after an endurance exercise: A real-life pilot study at the Paris Marathon. J Sci Med Sport. 2021 Nov;24(11):1100-1104. doi: 10.1016/j.jsams.2021.03.013. Epub 2021 Mar 30.

  PMID: 33824079 DERIVED

MeSH Terms

Interventions

Blood Pressure Determination

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Physical Examination

Study Officials

• Martine MAUGET FAYSSE

  Fondation A. de Rothschild

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2019
• First Posted: March 6, 2019
• Study Start: March 15, 2019
• Primary Completion: April 14, 2019
• Study Completion: May 6, 2019
• Last Updated: May 7, 2019

Record last verified: 2019-05

Locations

FR (1)