Screening for Depression in cADiovasCular pAtients at a Tertiary Center in Trinidad.

NCT03863262 | Completed

• 1 other identifier: CEC691/08/18
• Study Type: observational
• Target: 1,203
• Locations: 1 country
• Sites: 2

Brief Summary

This was an observational study aimed to screen patients with cardiovascular disease for depression in Trinidad and Tobago in a tertiary center and to determine if there is a significant association between patients with symptoms of depression and other comorbidities. Patients (N=1203) were randomly selected from the outpatient cardiology clinics at the Eric Williams Medical Sciences Complex. After fulfilling the inclusion criteria and informed consent were obtained, they were given the case report form which included the Patient Health Questionnaire 9.

Conditions

Depression

Keywords

cardiovascular

Outcome Measures

Primary Outcomes (1)

• Percentage of cardiovascular patients with a PHQ9 Score > 10

  The percentage of cardiovascular patients with a screening for depression score \> 10.

  4 months

Secondary Outcomes (1)

• Demographic associations with a PHQ9 Score >10.

  4 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The number of participants in this study was 1203 patients. There were no dropped subjects from the study nor were there any incomplete questionnaires by any participants. The sample size for this study was calculated to be 1159 patients. Based on a study done by Huffman, it was estimated that 40% of patients with cardiovascular disease also have depression(2). The Type I error rate 5% (α = 0.05) making the Type II error rate 95% (β = 0.95) with a statistical power of 90%. Assuming a 10% patient decline and attrition rate and a minimum detectable difference of 10%, the estimated sample size was calculated to be 1159 patients.

You may qualify if:

• Registered patients at Eric Williams Medical Sciences Complex in any of the cardiology outpatient clinics. This was confirmed by matching patients with their registration numbers on the cardiology outpatient clinic appointment listings. These lists are made prior to each cardiology clinic that is scheduled every week on Mondays, Tuesdays, Wednesdays, Thursdays and Fridays.
• Patients who were 18 years old

You may not qualify if:

• Patients less than 18 years old
• Those who did not give informed consent to participate in the study
• Patients who were not registered patients of the cardiology outpatient clinics at Eric Williams Medical Sciences Complex along
• Patients who were acutely unwell requiring hospital admission

Sponsors & Collaborators

• The University of The West Indies: lead

Study Sites (2)

Eric Williams Medical Sciences Complex

Port of Spain, North, 00000, Trinidad and Tobago

Location

The University of the West Indies

Saint Augustine, North, 000000, Trinidad and Tobago

Location

Related Publications (6)

• Huffman JC, Celano CM, Beach SR, Motiwala SR, Januzzi JL. Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Cardiovasc Psychiatry Neurol. 2013;2013:695925. doi: 10.1155/2013/695925. Epub 2013 Apr 7.

  PMID: 23653854 RESULT

• Zellweger MJ, Osterwalder RH, Langewitz W, Pfisterer ME. Coronary artery disease and depression. Eur Heart J. 2004 Jan;25(1):3-9. doi: 10.1016/j.ehj.2003.09.009.

  PMID: 14683736 RESULT

• Whooley MA. Depression and cardiovascular disease: healing the broken-hearted. JAMA. 2006 Jun 28;295(24):2874-81. doi: 10.1001/jama.295.24.2874.

  PMID: 16804154 RESULT

• Wittkampf K, van Ravesteijn H, Baas K, van de Hoogen H, Schene A, Bindels P, Lucassen P, van de Lisdonk E, van Weert H. The accuracy of Patient Health Questionnaire-9 in detecting depression and measuring depression severity in high-risk groups in primary care. Gen Hosp Psychiatry. 2009 Sep-Oct;31(5):451-9. doi: 10.1016/j.genhosppsych.2009.06.001. Epub 2009 Jul 10.

  PMID: 19703639 RESULT

• Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.

  PMID: 11556941 RESULT

• Seecheran N, Jagdeo CL, Seecheran R, Seecheran V, Persad S, Peram L, Evans M, Edwards J, Thackoorcharan S, Davis B, Davis S, Dawkins B, Dayaram A, De Freitas M, Deonarinesingh T, Dhanai J, Didier C, Motilal S, Baboolal N. Screening for depressive symptoms in cardiovascular patients at a tertiary centre in Trinidad and Tobago: investigation of correlates in the SAD CAT study. BMC Psychiatry. 2020 Oct 8;20(1):498. doi: 10.1186/s12888-020-02909-1.

  PMID: 33032571 DERIVED

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 20, 2019
• First Posted: March 5, 2019
• Study Start: November 8, 2018
• Primary Completion: February 20, 2019
• Study Completion: February 20, 2019
• Last Updated: December 3, 2019

Record last verified: 2019-11

Data Sharing

• IPD Sharing: Will not share

Locations

TR (2)