NCT03857724

Brief Summary

The levator ani muscle seems to play a key role in pelvic floor dysfunction. This muscle has two major components, the pubovisceral (including the pubococcygeus and puborectalis muscles) and the iliococcygeal muscles.Major levator ani defects are associated with pelvic organ prolapse (POP) and POP recurrence

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2019

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 26, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 28, 2019

Completed
4 months until next milestone

Study Start

First participant enrolled

July 1, 2019

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2021

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2021

Completed
Last Updated

March 5, 2019

Status Verified

March 1, 2019

Enrollment Period

2 years

First QC Date

February 26, 2019

Last Update Submit

March 3, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • levator hiatus area in cm2 in women with POP before and after apical prolapse surgeries.

    levator hiatus area in cm2 in women with POP before and after apical prolapse surgeries.

    2 years

Study Arms (1)

prolapse surgery

EXPERIMENTAL
Procedure: prolapse surgery

Interventions

prolapse surgery

prolapse surgery

Eligibility Criteria

Sexfemale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • I. Arabic female that is able to understand the instructions and the questionnaires that will be given II. Apical prolapse Stage 2-4 (according to POP-Q)(30,33) III. Sexually active (at least 3 times every month)

You may not qualify if:

  • Pregnancy
  • Postpartum women during the 1st 6 months postpartum
  • Human papillomavirus vulvar disease (condyloma acuminata)
  • Patient unfit for surgery
  • Previous pelvic reconstruction surgery.
  • Factors affecting healing process as uncontrolled diabetes, steroid therapy, on chemotherapy,….. etc

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Women Health Hospital

Asyut, Egypt

Location

Related Publications (2)

  • Rinne KM, Kirkinen PP. What predisposes young women to genital prolapse? Eur J Obstet Gynecol Reprod Biol. 1999 May;84(1):23-5. doi: 10.1016/s0301-2115(99)00002-0.

  • Lin KL, Juan YS, Chou SH, Long CY. Ultrasonographic Assessment with Three-Dimensional Mode of the Urethral Compression Effect following Sling Surgery with and without Mesh Surgery. Biomed Res Int. 2019 Jan 6;2019:8285351. doi: 10.1155/2019/8285351. eCollection 2019.

MeSH Terms

Conditions

Pelvic Organ Prolapse

Condition Hierarchy (Ancestors)

ProlapsePathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principal investigator

Study Record Dates

First Submitted

February 26, 2019

First Posted

February 28, 2019

Study Start

July 1, 2019

Primary Completion

July 1, 2021

Study Completion

September 1, 2021

Last Updated

March 5, 2019

Record last verified: 2019-03

Locations