Impact of Residual Renal Function on Complications in Chronic Hemodialysis Patients

NCT03854513 | Unknown

• 1 other identifier: Impact of HD on Kidneys
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Our aim is to study the impact of residual renal function on hemodialysis patients mortality and morbidity .

Conditions

Hemodialysis Complication

Outcome Measures

Primary Outcomes (1)

• determine complications of hemodialysis on patients with chronic kidney disease

  impact of residual renal function on hemodialysis patients mortality and morbidity and imprtance of high residual renal function on patients lifespan \- residual renal function will assess by GFR which assess by MDRD and creatinine clearance methods

  baseline

Study Arms (2)

-Group 1 (anuric)

patients on maintenance hemodialysis after 6 months to 1 year or more and urinary output less than 100ml / day

Device: dialysis machine

Group 2 (good UOP)

patients on maintenance hemodialysis after 6 months to 1 year or more and urinary output 400ml / day or more

Device: dialysis machine

Interventions

dialysis machine DEVICE

A machine used in dialysis that filters a patient's blood to remove excess water and waste products when the kidneys are damaged

-Group 1 (anuric); Group 2 (good UOP)

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: male
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

any populatin

You may qualify if:

• Chronic renal failure patients on maintenance hemodialysis after at least six months.

You may not qualify if:

• Obstructive uropathy.
• Heart failure.
• Chronic liver disease( decompensated liver cirrhosis and ascites).

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Hu SL, Joshi P, Kaplan M, Lefkovitz J, Poenariu A, Dworkin LD, Michaud DS. Rapid Change in Residual Renal Function Decline Is Associated with Lower Survival and Worse Residual Renal Function Preservation in Peritoneal Dialysis Patients. Perit Dial Int. 2017 Jul-Aug;37(4):477-481. doi: 10.3747/pdi.2016.00211.

  PMID: 28676514 BACKGROUND

• Cho HY, Hyun HS, Kang HG, Ha IS, Cheong HI. Prevalence of 25(OH) vitamin D insufficiency and deficiency in pediatric patients on chronic dialysis. Perit Dial Int. 2013 Jul-Aug;33(4):398-404. doi: 10.3747/pdi.2011.00246. Epub 2012 Dec 3.

  PMID: 23209039 BACKGROUND

• Maksic D, Colic M, Stankovic-Popovic V, Radojevic M, Bokonjic D. Systemic and intraperitoneal proinflammatory cytokines profiles in patients on chronic peritoneal dialysis. Med Pregl. 2007;60 Suppl 2:53-7.

  PMID: 18928158 BACKGROUND

• Kazmi WH, Gilbertson DT, Obrador GT, Guo H, Pereira BJ, Collins AJ, Kausz AT. Effect of comorbidity on the increased mortality associated with early initiation of dialysis. Am J Kidney Dis. 2005 Nov;46(5):887-96. doi: 10.1053/j.ajkd.2005.08.005.

  PMID: 16253729 BACKGROUND

MeSH Terms

Interventions

Kidneys, Artificial

Intervention Hierarchy (Ancestors)

Artificial Organs; Surgical Equipment; Equipment and Supplies

Study Officials

• Mohammed A. Sobh

  Assuit Univeristy

  STUDY DIRECTOR

Central Study Contacts

Abd el_rahman H. Mohy eldein

CONTACT

0201009749401; Drabdelrahman.mohyeldein@gmail.com

Mohammed A. SOBH, Prof

CONTACT

0201069272669

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: February 14, 2019
• First Posted: February 26, 2019
• Study Start: February 26, 2019
• Primary Completion: February 15, 2020
• Study Completion: April 20, 2020
• Last Updated: February 26, 2019

Record last verified: 2019-02