Positive Pressure and Gravity Affect Volumetric Capnography
The Effect of Positive Pressure and Body Position on Volumetric Capnography Assessed by Electrical Impedance Tomography
1 other identifier
interventional
10
1 country
1
Brief Summary
Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2016
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 3, 2015
CompletedStudy Start
First participant enrolled
February 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 21, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
February 21, 2019
CompletedFirst Posted
Study publicly available on registry
February 25, 2019
CompletedFebruary 25, 2019
February 1, 2016
3.1 years
March 3, 2015
February 21, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Analysis of the changes in volumetric capnographic parameters with changes in body positioning and positive pressure ventilation.
The volunteers are breathing spontaneously with and without positive pressure support. Capnographic parameters were registered at each studied condition.
4 hours
Secondary Outcomes (1)
Electrical impedance images of the distribution of ventilation with changes in body positioning and positive pressure ventilation.
4 hours
Study Arms (1)
non-invasive ventilation
EXPERIMENTALNon-invasive positive pressure at different body positions: sitting - supine - prone - right lateral and left lateral.
Interventions
positive pressure ventilation at different body positions
Eligibility Criteria
You may qualify if:
- American Society Anesthesia physical status I.
- Age between 25-39 years old,
- Body mass index between 23-28 kg/m2,
- Non-smokers.
You may not qualify if:
- Presence of pulmonary or cardiac diseases.
- Abnormal spirometry.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital Privado de Comunidad
Mar del Plata, Buenos Aires, 7600, Argentina
Related Publications (2)
Costa EL, Lima RG, Amato MB. Electrical impedance tomography. Curr Opin Crit Care. 2009 Feb;15(1):18-24. doi: 10.1097/mcc.0b013e3283220e8c.
PMID: 19186406BACKGROUNDTusman G, Scandurra A, Bohm SH, Suarez-Sipmann F, Clara F. Model fitting of volumetric capnograms improves calculations of airway dead space and slope of phase III. J Clin Monit Comput. 2009 Aug;23(4):197-206. doi: 10.1007/s10877-009-9182-z. Epub 2009 Jun 11.
PMID: 19517259BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gerardo H Tusman, MD
Hospital Privado de Comunidad
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 3, 2015
First Posted
February 25, 2019
Study Start
February 1, 2016
Primary Completion
February 21, 2019
Study Completion
February 21, 2019
Last Updated
February 25, 2019
Record last verified: 2016-02
Data Sharing
- IPD Sharing
- Will not share