Inhibitory Control and Eating Disorders

NCT03850288 | Completed

• 1 other identifier: 69HCL18_0621
• Study Type: observational
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

Executive functions are part of the high-level cognitive processes essential to the proper functioning of human cognition. They consist mainly of flexibility, updating and inhibition. Some studies have shown a correlation between executive disorders (impaired executive function) and psychiatric disorders such as obsessive-compulsive disorder or phobias. These executive disorders are related to dysfunctions of the fronto-striatal loops. In addition, other studies have investigated the link that may exist between eating disorders such as anorexia or bulimia nervosa and executive functioning. Anorexia nervosa, bulimia nervosa and binge eating disorders are eating disorders characterized by a dysfunction in food intake with restriction of food or compulsions as well as strong concerns about the body schema. Concerning the executive functioning, these studies highlight a lack of cognitive flexibility for patients with anorexia nervosa and bulimia nervosa but also dysfunctions depending on the type of pathology (anorexia nervosa or bulimia nervosa). These studies also highlight the beneficial effects of cognitive remediation on people with eating disorders. However, the investigation of the inhibitory control has not yet been specifically studied. Moreover, since eating disorders are structurally different, a comparison between several pathologies would be interesting to consider. The aim of this study is to determine if a dysfunction of inhibitory control can be highlighted in people with eating disorders. This study would also allow further researches about cognitive remediation suitable for the specific difficulties encountered in these diseases.

Conditions

Anorexia Nervosa; Bulimia Nervosa; Binge Eating

Outcome Measures

Primary Outcomes (5)

• Inhibition processes assessment - the Stroop task, Execution time

  Execution time in the Stroop task

  1 day

• Inhibition processes assessment - the Stroop task, Errors

  Errors in the Stroop task

  1 day

• Inhibition processes assessment - the Go No Go task, Execution time

  Execution time in the Go No Go task.

  1 day

• Inhibition processes assessment - the Go No Go task, Variability of execution time

  Variability of execution time in the Go No Go task

  1 day

• Inhibition processes assessment - the Go No Go task, Errors

  Errors in the Go No Go task

  1 day

Study Arms (3)

Anorexia Nervosa

Patients with a diagnosis of anorexia nervosa (According to the DSM-V criteria). These patients are characterized by a restriction of food intake leading to weight loss or a failure to gain weight resulting in a "significantly low body weight" of what would be expected for someone's age, sex and height. Moreover, there is a fear of becoming fat or of gaining weight.Then, these patients have a distorted view of themselves and of their condition.

Other: Neuropsychological assessment : Stroop task; Other: Neuropsychological assessment : Go No Go task

Bulimia Nervosa

Patients with a diagnosis of bulimia nervosa. According to the DSM-V criteria, these patients are characterized by recurrent episodes of binge eating (eating, in a discrete period of time, an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances), a sense of lack of control over eating during the episode, recurrent inappropriate compensatory behaviour in order to prevent weight gain, such as self-induced vomiting, misuse of laxatives, diuretics, or other medications, fasting, or excessive exercise. The binge eating and inappropriate compensatory behaviours both occur, on average, at least once a week for three months. Moreover, there is a self-evaluation influenced by body shape and weight.

Other: Neuropsychological assessment : Stroop task; Other: Neuropsychological assessment : Go No Go task

Binge Eating Disorder

Patients with a diagnosis of Binge Eating Disorder. These patients are characterized by recurrent episodes of binge eating (eating, in a discrete period of time (e.g. within any 2-hour period), an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances), a sense of lack of control over eating during the episode. The binge eating episodes are associated with three or more of the following: eating much more rapidly than normal, eating until feeling uncomfortably full, eating large amounts of food when not feeling physically hungry, eating alone because of feeling embarrassed by how much one is eating, feeling disgusted with oneself, depressed or very guilty afterward,marked distress regarding binge eating is present. Moreover, binge eating occurs, on average, at least once a week for three months

Other: Neuropsychological assessment : Stroop task; Other: Neuropsychological assessment : Go No Go task

Interventions

Neuropsychological assessment : Stroop task OTHER

Stroop task is an interference task assessing cognitive inhibitory control. This "paper-and-pencil" task aims to evaluate the inhibition of an automated process such as reading by asking participants to name the color of color names written in a different color ink. This test is non-invasive.

Anorexia Nervosa; Binge Eating Disorder; Bulimia Nervosa

Neuropsychological assessment : Go No Go task OTHER

Go No Go task assessing motor inhibitory control. This computer-based task is designed to evaluate motor inhibition by asking participants to respond to a stimulus as quickly as possible by inhibiting another distractor stimulus. This test is non-invasive.

Anorexia Nervosa; Binge Eating Disorder; Bulimia Nervosa

Eligibility Criteria

• Age: 19 Years - 40 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women aged 19 to 40 years old, with a BMI between 13 and 40 kg/m2, outpatients of the Refering Center of Eating Disorders ('Hospices Civils de Lyon' in Lyon), with an eating disorder diagnosis (Anorexia Nervosa, Bulimia Nervosa or Binge Eating Disorder).

You may qualify if:

• Woman aged 19 to 40 years old
• Patient with a BMI between 13 and 40 kg/m2
• Outpatients of the Refering Center of Eating Disorders ('Hospices Civils de Lyon' in Lyon) suffering of an eating disorder diagnosis (Anorexia Nervosa, Bulimia Nervosa or Binge Eating Disorder)
• Patient who agrees to participate to the study.

You may not qualify if:

• Major patient protected by a measure of legal protection
• Patient younger than 19 years old
• Participation to another study at the same time

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Centre Référent pour l'Anorexie et les Troubles du Comportement Alimentaire

Bron, 69500, France

Location

MeSH Terms

Conditions

Anorexia Nervosa; Bulimia Nervosa; Bulimia

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders; Hyperphagia; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 15, 2019
• First Posted: February 21, 2019
• Study Start: May 15, 2019
• Primary Completion: February 26, 2020
• Study Completion: February 26, 2020
• Last Updated: March 6, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)