NCT03849248

Brief Summary

To study the effect of maternal scent on the oral feeding, behavior and stress level of premature infants hospitalized in the Neonatal intensive care unit and to assess its potential effect on their development at 18 to 24 months.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
132

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 24, 2019

Completed
28 days until next milestone

First Posted

Study publicly available on registry

February 21, 2019

Completed
3 months until next milestone

Study Start

First participant enrolled

May 24, 2019

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2023

Completed
Last Updated

April 5, 2022

Status Verified

April 1, 2022

Enrollment Period

3.8 years

First QC Date

January 24, 2019

Last Update Submit

April 4, 2022

Conditions

Keywords

maternal scentinfant behaviorfeeding patternsstress levels

Outcome Measures

Primary Outcomes (1)

  • Salivary cortisol level

    The saliva will be collected from infant mouth after enrollment the first day before placing the scented cloth under the infant's head and the second after the exposure to the second cloth. Levels will be compared before and after and between groups.

    Two years

Secondary Outcomes (2)

  • Physiological parameters: Heart rate and respiratory rate

    Two years

  • Achievement of oral feeding

    Two years

Study Arms (2)

Intervention

EXPERIMENTAL

This group of babies will have a maternal scented cloth placed under their heads

Other: Maternal scent cloth

Control

NO INTERVENTION

This group of babies will have a clean non- maternal scented cloth placed under their head

Interventions

The babies assigned to the intervention group will have a cloth with their mother's scent on it placed under their heads.

Intervention

Eligibility Criteria

Age5 Days - 10 Days
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Mother of a baby who was born premature before completing 36 weeks of pregnancy
  • Baby between ages of 5-10 days
  • Medically stable baby
  • Baby already began feeding by mouth or by feeding tube

You may not qualify if:

  • Medically unstable baby born after 36 weeks of gestation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

American University of Beirut

Beirut, 1107 2020, Lebanon

RECRUITING

MeSH Terms

Conditions

Infant BehaviorFeeding Behavior

Condition Hierarchy (Ancestors)

Child BehaviorBehaviorBehavior, Animal

Study Officials

  • Lama Charafeddine, MD

    American University of Beirut Medical Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Saadieh Masri, RN

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Pediatrics and Neonatology

Study Record Dates

First Submitted

January 24, 2019

First Posted

February 21, 2019

Study Start

May 24, 2019

Primary Completion

March 1, 2023

Study Completion

March 1, 2023

Last Updated

April 5, 2022

Record last verified: 2022-04

Locations