Retrograde Reperfusion Versus Antegrade Liver Transplant Reperfusion

NCT03846089 | Withdrawn

• 1 other identifier: 106793
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

A retrospective cohort analysis was performed comparing patients that had intra operative antegrade liver reperfusions versus patients that had retrograde liver perfusion.

Conditions

Liver Transplant Failure

Outcome Measures

Primary Outcomes (1)

• Graft survival

  Average length of time the liver graft remains in a living recipient regardless of function

  From date of transplantation until the date of next transplantation or date of death from any cause, whichever came first, assessed up to 300 months

Secondary Outcomes (1)

• Patient survival

  From date of transplantation until the date of death from any cause assessed up to 300 months

Study Arms (2)

Retrograde reperfusion

After completion of the inferior vena cava anastomosis, the clamps were removed to allow retrograde reperfusion of the graft.

Procedure: Graft reperfusion

Antegrade reperfusion

After completion of the inferior vena cava anastomosis, the portal vein anastomosis is completed and then the clamps were removed to allow antegrade reperfusion of the graft.

Procedure: Graft reperfusion

Interventions

Graft reperfusion PROCEDURE

antegrade (forward) or retrograde (backward) blood reperfusion of the liver graft

Antegrade reperfusion; Retrograde reperfusion

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who have undergone transplantation of the liver at LHSC.

You may qualify if:

• all liver transplantations between 1 Jan 2002 and 31 Dec 2005

You may not qualify if:

• liver retransplantation
• multiorgan transplantation
• ABO incompatible transplantation

Sponsors & Collaborators

• London Health Sciences Centre: lead

Study Officials

• Vivian McAlister

  London Health Sciences Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Surgery

Study Record Dates

• First Submitted: February 16, 2019
• First Posted: February 19, 2019
• Study Start: January 1, 2002
• Primary Completion: December 31, 2005
• Study Completion: February 28, 2020
• Last Updated: April 6, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR, ANALYTIC CODE
• Time Frame: From the time of publication for 5 years
• Access Criteria: By contacting the PI and with permission of the REB