Urine Iodine Levels of Surgical Staff

NCT03845777 | Completed

• 1 other identifier: Capa Iyot
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The routine use of topical iodinated antiseptic could be a possible cause of iodine contamination. The aim of this study is to evaluate iodine concentrations in operation-room staff who routinely use iodine-containing antiseptics for cleansing of the hands after salt iodization. Methods: The study included 40 surgeons and surgical nurses who use surgical hand-scrub solutions. Participants applied an iodized brush for a minimum of three times a day on weekdays and were iodine-free on the weekends. Morning spot urine specimens were collected from all participants to analyze the urinary iodine concentration (UIC) twice a week.

Conditions

Urine Iodine

Keywords

Iodine; Surgical; Staff; Antiseptic

Outcome Measures

Primary Outcomes (1)

• Urine Iodine

  The subjects used iodine-containing hand scrub solutions on weekdays and were iodine-free on the weekends. Early-morning spot urine specimens were collected from all participants to analyze the UIC twice a week: once at the beginning of the working period (the washout period of the antiseptic) and once at the end of the working period (the antiseptic exposure period).

  1 week

Study Arms (1)

Surgical Staff

The surgical staff group is the only group of the study. Blood samples of the surgical staff before and after the using antiseptics solution that include iodine were analyzed.

Diagnostic Test: Using Antiseptic solution

Interventions

Using Antiseptic solution DIAGNOSTIC_TEST

Using of iodine including antiseptic solutions. The investigators investigate the urine iodine status of staff before and after the using of antiseptic solution

Surgical Staff

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The surgical staff used iodine-containing hand scrub solutions for antisepsis

You may qualify if:

• Surgical staff

You may not qualify if:

• goiter
• hypertension
• thyroidectomy history

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead
• Istanbul University: collaborator

Study Sites (1)

Istanbul University

Istanbul, 34452, Turkey (Türkiye)

Location

Related Publications (3)

• Erdogan MF, Tatar FA, Unluturk U, Cin N, Uysal AR. The effect of scrubbing hands with iodine-containing solutions on urinary iodine concentrations of the operating room staff. Thyroid. 2013 Mar;23(3):342-5. doi: 10.1089/thy.2012.0325.

  PMID: 23234312 RESULT

• Grasso L, Maxia PL, Bartalena L, Murtas ML, Taberlet A, Martino E. Iodine contamination in subjects admitted to a general hospital. J Endocrinol Invest. 1992 Apr;15(4):307-8. doi: 10.1007/BF03348739.

  PMID: 1512422 RESULT

• Michalaki M, Pylioti A, Loutas V, Mamali I, Markou KB. Absence of differences in urinary iodine excretion and thyroid function tests in operating room staff members using or not using iodine-containing antiseptic solutions. Thyroid. 2013 Dec;23(12):1659-60. doi: 10.1089/thy.2013.0218. Epub 2013 Aug 1. No abstract available.

  PMID: 23724900 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood

Study Officials

• Sema Yarman, Prof.

  Istanbul University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 4 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: February 16, 2019
• First Posted: February 19, 2019
• Study Start: November 1, 2017
• Primary Completion: February 28, 2018
• Study Completion: November 30, 2018
• Last Updated: February 20, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)