NCT03845569|Completed
Influence of Habitual Protein Intake on AA Tracer Oxidation
HPI
Impact of Habitual Protein Intake on Estimates of Dietary Protein Requirements in Resistance Trained Athletes
Loading search results
HPI
Impact of Habitual Protein Intake on Estimates of Dietary Protein Requirements in Resistance Trained Athletes
Sponsor study identifier
interventional
5
1 country
1
Study Start
November 1, 2017
Actual (reported)Primary Completion
April 18, 2018
Actual (reported)Study Completion
April 18, 2018
Actual (reported)Protein is an essential nutrient that one's diet to maintain important bodily functions and to recover from exercise. Currently, the Indicator Amino Acid Oxidation method (IAAO) has been used to determine protein requirements in a variety of populations including children, neonates, the elderly and recently, resistance trained populations. This study serves to test the robustness of the IAAO method and to determine if high habitual dietary protein intake, as seen in resistance trained males, has the potential to influence the protein requirements determined by the IAAO method. Further, the current study also aims to determine how the body metabolizes or uses dietary protein and how it might change when consuming a protein intake that is less than what is habitually consumed.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 18, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 1, 2017
Actual (reported)April 18, 2018
Actual (reported)April 18, 2018
Actual (reported)February 13, 2019
Actual (reported)February 19, 2019
Actual (reported)Phenylalanine excretion (F13CO2)
Expressed as µmol/kg/h; phenylalanine excretion is determined via breath enrichment (F13CO2) of the oral tracer. Breath 13CO2 enrichment was measured by continuous-flow isotope ratio mass spectrometry
Through study completion, an average of 3 months
Phenylalanine oxidation (PheOX)
Expressed as µmol/kg/h; phenylalanine excretion is determined via breath and urine enrichment of the oral tracer. Breath 13CO2 enrichment was measured by continuous-flow isotope ratio mass spectrometry and urinary L-\[1-13C\] phenylalanine was measured by liquid chromatography tandem mass spectrometry
Through study completion, an average of 3 months
A trial investigating protein oxidation/metabolism that was used to model resistance trained individual's habitual dietary protein intake (2.2g/kg/d).
A series of three trials over a one week period investigating protein oxidation/metabolism that was used to investigate the metabolic response of decreased protein intake (1.2g/kg/d) over a period of five days (trials on days 1, 3, 5 following reduction in protein intake from 2.2g/kg/d to 1.2g/kg/d) relative to the Habitual protein phase trial.
Following two days of controlled diet at 2.2g/kg/d of dietary protein, intake was reduced to 1.2g/kg/d for five days, and protein metabolism was measured on days 1, 3, and 5.
Three days of a controlled diet providing 2.2g/kg/d of dietary protein with protein metabolism measured on day 3. This was used to model the habitual intake of this cohort.
Goldring Centre for High Performance Sport
Toronto, Ontario, M5S 2C9, Canada
Tinline-Goodfellow CT, West DWD, Malowany JM, Gillen JB, Moore DR. An Acute Reduction in Habitual Protein Intake Attenuates Post Exercise Anabolism and May Bias Oxidation-Derived Protein Requirements in Resistance Trained Men. Front Nutr. 2020 Apr 22;7:55. doi: 10.3389/fnut.2020.00055. eCollection 2020.
Daniel R Moore, PhD
University of Toronto
5 participants (actual enrollment reported by the registry).
First Submitted
February 13, 2019
First Posted
February 19, 2019
Study Start
November 1, 2017
Actual (reported)Phenylalanine Rate of Appearance (PheRa/Flux)
Through study completion, an average of 3 months
Net Protein Balance
Through study completion, an average of 3 months
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
April 18, 2018
Actual (reported)Study Completion
April 18, 2018
Actual (reported)Last Updated
February 19, 2019
Record last verified: 2019-02
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: