Suitability of PICC for Transpulmonary Thermodilution Compared to CICC

NCT03834675 | Completed

• 1 other identifier: PICC -CICC for TPTD
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Peripherally inserted central catheters (PICCs) are increasingly used in intensive care unit (ICU) as an alternative to centrally inserted central catheters (CICCs) for intravenous infusion. In the present study we try to assess their reliability for measuring cardiac index (CI) with trans-pulmonary thermodilution (TPTD) technique.

Conditions

Peripherally Inserted Central Catheters; CVC; Transpulmonary Thermodilution; Hemodynamic Monitoring

Keywords

PICC; shock; cardiac output

Outcome Measures

Primary Outcomes (1)

• Cardiac Index comparison via PICC

  comparison of hemodynamic measurements made by the TPTD from the VolumeView/EV1000TM system via PICC vs. CICC.

  One hour

Secondary Outcomes (2)

• Comparison 4Fr PICCs to CICC

  one hour

• Comparison 5Fr PICCs to CICC

  one hour

Interventions

transpulmonary thermodilution DIAGNOSTIC_TEST

Thermodilution was attempted via PICC and via CICC

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• adult patients (≥18 years) admitted to the ICU
• Patients requiring hemodynamic monitoring using EV1000TM
• Patients having both PICC and CICC in place (these patients had their PICC replaced with a CICC, usually at the time of ICU admission, or vice versa, usually at the end of their ICU stay, and were enrolled immediately after the placement of the new device before the previous one was removed)

You may not qualify if:

• body weight \<40 kg
• severe aortic regurgitation or intra-cardiac shunt
• treatment with an intra-aortic balloon pump
• contraindication for placement of PICC, CICC or a femoral arterial catheter
• abdominal aneurism
• extracorporeal circulation
• pregnancy
• lack of informed consent

Sponsors & Collaborators

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS: lead
• Claudio Sandroni: collaborator
• Sofia Cacciola: collaborator
• Antonio Maria Dell Anna: collaborator
• Mauro Pittiruti: collaborator
• Maria Giuseppina Annetta: collaborator
• Cesare Colosimo: collaborator
• Massimo Antonelli: collaborator

Study Sites (1)

Fondazione Policlinico Universitario A. Gemelli IRCCS

Roma, 00168, Italy

Location

Related Publications (1)

• D'Arrigo S, Sandroni C, Cacciola S, Dell'Anna AM, Pittiruti M, Annetta MG, Colosimo C, Antonelli M. Are Peripherally Inserted Central Catheters Suitable for Cardiac Output Assessment With Transpulmonary Thermodilution? Crit Care Med. 2019 Oct;47(10):1356-1361. doi: 10.1097/CCM.0000000000003917.

  PMID: 31356470 DERIVED

MeSH Terms

Conditions

Shock

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Massimo Antonelli, MD

  Università Cattolica del sacro Cuore- Fondazione Policlinico Universitario A. Gemelli IRCSS

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor - PhD

Study Record Dates

• First Submitted: February 5, 2019
• First Posted: February 8, 2019
• Study Start: June 1, 2018
• Primary Completion: December 31, 2018
• Study Completion: January 31, 2019
• Last Updated: January 27, 2020

Record last verified: 2019-02

Locations

IT (1)