Enterobius Vermicularis and Bruxism in Children

NCT03833505 | Completed DMC FDA Drug

• 1 other identifier: 2017/003-24.03.2017
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Background. Bruxism is an involuntary, non-functional activity of the masticatory system, and is frequently seen in childhood. Bruxism has many aetiologies, like malocclusion, psychological factors, allergies and gastrointestinal disorders. Aim. To investigate the relationship between Enterobius vermicularis infection and bruxism in children.

Conditions

Bruxism, Sleep

Outcome Measures

Primary Outcomes (1)

• Survey

  The parents of the patients were asked to complete a survey that included questions about the demographic data, medical history of the patient, clinical findings of E. vermicularis and bruxism, other harmful oral habits, family life and habits.

  24.03.2017-20.05.2018

Secondary Outcomes (1)

• Oral examination

  24.03.2017-20.05.2018

Other Outcomes (1)

• BiteStrip

  24.03.2017-20.05.2018

Study Arms (2)

Group 1,

E. vermicularis-positive

Other: Bitestrip

Group 2

E. vermicularis-negative

Other: Bitestrip

Interventions

Bitestrip OTHER

The parents of the patients were asked to complete a survey that included questions about the demographic data, medical history of the patient, clinical findings of E. For diagnosis of sleep bruxism, a single-use BiteStrip® device (Up2dent, Inc.), including an electromyographic electrode, small display screen and lithium cell, was used to record the increased electromyographic activity of the masticatory muscles during sleep and bruxism, other harmful oral habits, family life and habits.

Group 1,; Group 2

Eligibility Criteria

• Age: 3 Years - 10 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The study included E. vermicularis-positive (Group 1, n =13) and E. vermicularis-negative (Group 2: n = 13) children aged between 3-10 years, who were admitted to Aydın Adnan Menderes University Faculty of Medicine Paediatric Gastroenterology Clinic.

You may qualify if:

• Teeth-grinding at least once a week in the last 3 months before recruitment according to the criteria established by the American Academy of Sleep Medicine (AASM)
• Angle class I occlusion
• Mesial step occlusion according to flush terminal plane.

You may not qualify if:

• Treated with anti-helminthic drugs in the last 2 months before recruitment
• Drugs used that could affect the central nervous system and prevent sleep (sedatives, anti-depressants, neuroleptics, anti-muscarinics, selective serotonin re-uptake inhibitors)
• Sleep disorders (snoring, insomnia, obstructive sleep apnoea, restless leg syndrome, sleep-related epilepsy)
• Psychiatric or neurological disorders
• Upper respiratory system obstruction (last 15 days),
• Any systemic disease;
• Teeth erosion due to internal (reflux) or external (acidic drinks) factors
• Dermatological problems, associated with the use of BiteStrip (Up2dent, Inc., Pulheim, Germany);
• Unsuitable skin structure;
• Previously diagnosed and treated for bruxism;
• Angle class II or class III occlusion

Sponsors & Collaborators

• Aydin Adnan Menderes University: lead

Study Sites (1)

Adnan Menderes University, Faculty of Dentistry, Department of Pediatric Dentistry

Aydin, Turkey (Türkiye)

Location

Related Publications (10)

• Diaz-Serrano KV, da Silva CB, de Albuquerque S, Pereira Saraiva Mda C, Nelson-Filho P. Is there an association between bruxism and intestinal parasitic infestation in children? J Dent Child (Chic). 2008 Sep-Dec;75(3):276-9.

  PMID: 19040814 BACKGROUND

• Mistry P, Moles DR, O'Neill J, Noar J. The occlusal effects of digit sucking habits amongst school children in Northamptonshire (UK). J Orthod. 2010 Jun;37(2):87-92. doi: 10.1179/14653121042939.

  PMID: 20567031 BACKGROUND

• Tehrani MH, Pestechian N, Yousefi H, Sekhavati H, Attarzadeh H. The Correlation between Intestinal Parasitic Infections and Bruxism among 3-6 Year-Old Children in Isfahan. Dent Res J (Isfahan). 2010 Summer;7(2):51-5.

  PMID: 22013457 BACKGROUND

• Bortoletto CC, Cordeiro da Silva F, Salgueiro Mda C, Motta LJ, Curiki LM, Mesquita-Ferarri RA, Fernandes KP, Bussadori SK. Evaluation of electromyographic signals in children with bruxism before and after therapy with Melissa Officinalis L-a randomized controlled clinical trial. J Phys Ther Sci. 2016 Mar;28(3):738-42. doi: 10.1589/jpts.28.738. Epub 2016 Mar 31.

  PMID: 27134350 BACKGROUND

• Shochat T, Gavish A, Arons E, Hadas N, Molotsky A, Lavie P, Oksenberg A. Validation of the BiteStrip screener for sleep bruxism. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):e32-9. doi: 10.1016/j.tripleo.2007.03.009. Epub 2007 Jul 6.

  PMID: 17618147 BACKGROUND

• Emodi-Perlman A, Eli I, Friedman-Rubin P, Goldsmith C, Reiter S, Winocur E. Bruxism, oral parafunctions, anamnestic and clinical findings of temporomandibular disorders in children. J Oral Rehabil. 2012 Feb;39(2):126-35. doi: 10.1111/j.1365-2842.2011.02254.x. Epub 2011 Sep 15.

  PMID: 21916926 BACKGROUND

• Johansson A, Haraldson T, Omar R, Kiliaridis S, Carlsson GE. A system for assessing the severity and progression of occlusal tooth wear. J Oral Rehabil. 1993 Mar;20(2):125-31. doi: 10.1111/j.1365-2842.1993.tb01596.x.

  PMID: 8468624 BACKGROUND

• Karakis D, Dogan A. The craniofacial morphology and maximum bite force in sleep bruxism patients with signs and symptoms of temporomandibular disorders. Cranio. 2015 Jan;33(1):32-7. doi: 10.1179/2151090314Y.0000000009. Epub 2014 Jun 3.

  PMID: 25547142 BACKGROUND

• Van Wyk JA, Van Rensburg LJ, Heitmann LP. Schistosoma mattheei infection in cattle: the course of the intestinal syndrome, and an estimate of the lethal dose of cercariae. Onderstepoort J Vet Res. 1997 Mar;64(1):65-75.

  PMID: 9204506 BACKGROUND

• Karakis D, Dogan A, Bek B. Evaluation of the effect of two different occlusal splints on maximum occlusal force in patients with sleep bruxism: a pilot study. J Adv Prosthodont. 2014 Apr;6(2):103-8. doi: 10.4047/jap.2014.6.2.103. Epub 2014 Apr 22.

  PMID: 24843394 RESULT

MeSH Terms

Conditions

Sleep Bruxism

Condition Hierarchy (Ancestors)

Bruxism; Tooth Diseases; Stomatognathic Diseases; Parasomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Study Officials

• K. Görkem Ulu Güzel

  ADU Faculty of Dentistry Paediatric Dentistry Department

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof

Study Record Dates

• First Submitted: January 5, 2019
• First Posted: February 7, 2019
• Study Start: March 15, 2017
• Primary Completion: May 20, 2018
• Study Completion: August 15, 2018
• Last Updated: February 7, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)