Outcomes of Elderly Patients Admitted to the Intensive Care Unit With Severe Acute Cholangitis

NCT03831529 | Completed

• 1 other identifier: PSS2017/ANGIOCHOLREA-NOVY/NK
• Study Type: observational
• Target: 204
• Locations: 1 country
• Sites: 2

Brief Summary

The aging of the population goes along with an increased demand for intensive care among very elderly patients (above 75-80 years old). At the same time, there is a decline in the supply of intensive care units (ICU). The 1-year mortality of patients above 80 years old in ICU ranged from 40 to 70%. Moreover, many survivors suffer from long-term sequelae as poor quality of life, cognitive impairment and functional disability. It is unclear under what conditions older patients may benefit from ICU admission. Cholangitis frequently occured in older patient. Moreover, severe acute cholangitis is a potentially life threatening disease characterized by a biliary obstruction and an infection of the bile possibly evolving towards systemic infection, shock and death. Because of its potential rapid reversibility of symptom thanks to early intravenous antibiotics and biliary decompression with drainage, old patients suffering from acute cholangitis are easily admitted to intensive care unit. To date, there is a lack of data about the outcome in this population admitted to the intensive care unit with acute cholangitis. The aim of the current study is to describe the outcomes in elderly patients (\> 75 years old) admitted to the ICU with acute cholangitis and to identify prognostics factors associated with long term mortality (6 months).

Conditions

Cholangitis Infective; Elderly Person

Keywords

critically ill; mortality; outcome; treatment intensity level

Outcome Measures

Primary Outcomes (1)

• mortality

  rate of survivors and non survivors

  180 days

Secondary Outcomes (8)

• mortality

  90 days

• mortality

  28 days

• factors associated with 6 months mortality (underlying condition)

  Day 1

• factors associated with 6 months mortality (severity score)

  Day 1

• factors associated with 6 months mortality (Presence of hemodynamic failure)

  Up to 7 days

Study Arms (1)

ICU older patient

Older patient (\> 65 years old) admitted to ICU with severe acute cholangitis

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients \> 65 years old admitted to the ICU for acute severe cholangitis

You may qualify if:

• \> 65 years old
• ICU admission for acute cholangitis
• follow up in the same center after the ICU stay

You may not qualify if:

• none

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (2)

CHR Mercy

Metz, Lorraine, 57000, France

Location

Emmanuel NOVY

Vandœuvre-lès-Nancy, Lorraine, 54500, France

Location

Related Publications (1)

• Novy E, Carrara L, Remen T, Chevaux JB, Losser MR, Louis G, Guerci P. Prognostic factors associated with six month mortality of critically ill elderly patients admitted to the intensive care unit with severe acute cholangitis. HPB (Oxford). 2021 Mar;23(3):459-467. doi: 10.1016/j.hpb.2020.08.003. Epub 2020 Aug 22.

  PMID: 32839088 DERIVED

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 18, 2019
• First Posted: February 6, 2019
• Study Start: June 18, 2018
• Primary Completion: November 14, 2018
• Study Completion: January 15, 2019
• Last Updated: February 6, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)