Stress-Induced Inflammation and Reward Processing

NCT03828604 | Completed

• 1 other identifier: SIWB
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a key psychobiological pathway to anhedonic behavior; however, this pathway has not been demonstrated in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. The current placebo controlled study used a standardized laboratory stressor task to elicit an inflammatory response in a sample of a healthy young women and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.

Conditions

Stress, Psychological

Keywords

reward processing

Outcome Measures

Primary Outcomes (3)

• Probabilistic Reward Task - Reward Responsiveness

  Change in the magnitude of response bias from pre to post Trier Social Stress Task (TSST) or Placebo-TSST (P-TSST).

  Pre-TSST/P-TSST and 90 min post-TSST/P-TSST

• Effort Expenditure for Rewards Task - Reward Motivation

  Change in amount of hard trials chosen from pre to post-TSST/P-TSST (overall, and at 3 levels of probability of potential rewards; low, medium, and high)

  Pre-TSST/P-TSST and 120 min post-TSST/P-TSST

• Attentional Bias Task

  Change in attentional bias from pre to post-TSST/P-TSST

  Pre-TSST/P-TSST and 110 min post-TSST/P-TSST

Secondary Outcomes (2)

• Effort Expenditure for Rewards Task - Reward Sensitivity

  120 min post-TSST

• Face Morphing Task

  Pre-TSST/P-TSST and 115 min post-TSST/P-TSST

Other Outcomes (2)

• Depressive symptoms

  Change in depressive symptoms from study entry to 4-month follow-up

• Affective experience during the experimental session

  Entry, pre-TSST/P-TSST; during TSST/P-TSST; 60, 90, 120, 150 min post TSST/P-TSST

Study Arms (2)

Stress; Trier Social Stress Task

EXPERIMENTAL

5 min challenging speech task, 5 min challenging math task; performed in front of evaluators

Behavioral: Stress; Trier Social Stress Task

Placebo Trier Social Stress Task

ACTIVE COMPARATOR

5 min speech task, 5 min math task; performed alone

Behavioral: Placebo Trier Social Stress Task

Interventions

Stress; Trier Social Stress Task BEHAVIORAL

Standardized acute psychosocial stressor

Stress; Trier Social Stress Task

Placebo Trier Social Stress Task BEHAVIORAL

Active control version of the TSST

Placebo Trier Social Stress Task

Eligibility Criteria

• Age: 18 Years - 28 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• English fluency
• Age 18-28
• Biologically female

You may not qualify if:

• Current illness
• Presence or history of major medical conditions
• Current or past diagnosis of alcohol use disorder
• Use of tobacco
• Use of immune-altering medications
• Current pregnancy

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

Clinical and Translational Research Center, University of California, Los Angeles

Los Angeles, California, 90095, United States

Location

Related Publications (1)

• Boyle CC, Stanton AL, Eisenberger NI, Seeman TE, Bower JE. Effects of stress-induced inflammation on reward processing in healthy young women. Brain Behav Immun. 2020 Jan;83:126-134. doi: 10.1016/j.bbi.2019.09.023. Epub 2019 Sep 30.

  PMID: 31580931 DERIVED

MeSH Terms

Conditions

Stress, Psychological

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Officials

• Chloe C Boyle, PhD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

• Julienne E Bower, PhD

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Acute Psychosocial stress vs. Non-stress active control

Study Record Dates

• First Submitted: January 31, 2019
• First Posted: February 4, 2019
• Study Start: May 12, 2017
• Primary Completion: December 8, 2017
• Study Completion: May 9, 2018
• Last Updated: February 5, 2019

Record last verified: 2019-02

Locations

US (1)