Alternations of Multi-parameters Including Hemodynamic Concentration and Water Levels During Dehydration Therapy on Brain Edema Patients
Sponsor study identifier
interventional
80
0 countries
N/A
Study Start
September 1, 2019
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Primary Completion
November 1, 2019
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Study Completion
December 11, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline. The investigators used a self-made near infrared spectroscopy (NIRS) instrument to monitor the physiological changes noninvasively including oxyhemoglobin (\[HbO2\]), deoxy-hemoglobin (\[Hb\]), the derived change in blood volume (\[tHb\]) and water concentration on the forehead of brain edema patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 11, 2019
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 31, 2019
Actual (reported)February 4, 2019
Actual (reported)September 1, 2019
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November 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 11, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Δ[HbO2]
changes of oxyhemoglobin concentration
2 weeks
water concentration
water concentration of brain
2 weeks
intracranial pressure
2 weeks
Δ[Hb]
2 weeks
The participant receive mannitol injection to decrease intracranial pressure in the ward with optical probes on his/her forehead.
The participant receive hypertonic saline of specific concentration injection to decrease intracranial pressure in the ward with optical probes on his/her forehead.
Standard mannitol injection to decrease intracranial pressure of patients
Standard Hypertonic saline injection to decrease intracranial pressure of patients
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First Submitted
January 31, 2019
First Posted
February 4, 2019
Study Start
September 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
November 1, 2019
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 11, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 24, 2019
Record last verified: 2019-07
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Source: ClinicalTrials.gov.
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