Increasing PrEP Use in High-Risk Social Networks of African-American MSM in Underserved Low-Risk Cities
SNAP
1 other identifier
interventional
500
1 country
2
Brief Summary
This study evaluates the use of a social-network approach to encourage African-American men who have sex with men (AAMSM) to adopt pre-exposure prophylaxis (PrEP) to prevent HIV infection. Thirty-six networks of AAMSM will be recruited in Milwaukee, WI, and Cleveland, OH. Half of these networks will have their leaders trained to endorse PrEP to their social network members, and the other half will be given brief HIV prevention counseling.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jan 2019
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 24, 2019
CompletedStudy Start
First participant enrolled
January 24, 2019
CompletedFirst Posted
Study publicly available on registry
January 30, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 22, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedFebruary 19, 2025
February 1, 2025
5.2 years
January 24, 2019
February 18, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Self-report of pre-exposure prophylaxis (PrEP) use
Change in self-reported PrEP use
6 and 15 months
Secondary Outcomes (5)
Pre-Exposure Prophylaxis (PrEP) Knowledge
6 and 15 months
Pre-Exposure Prophylaxis Attitudes
6 and 15 months
Pre-Exposure Prophylaxis Norm Perceptions
6 and 15 months
Pre-Exposure Prophylaxis Intentions
6 and 15 months
Pre-Exposure Prophylaxis Self-Efficacy
6 and 15 months
Study Arms (2)
Social Network Approach
EXPERIMENTALParticipants will receive brief HIV counseling at baseline visit. Leaders of social networks will be determined using data from participants. These leaders will then be invited to attend a 5-session small-group training that will teach them how to communicate the benefits of PrEP to their social network members. All social network members will be asked about intervention exposure at 6- and 15-month followups.
Comparison
ACTIVE COMPARATORParticipants will receive brief HIV counseling at baseline visit.
Interventions
Leaders of social networks will be statistically determined. Over 5 small-group training sessions, these leaders will be trained to communicate to their social network members accurate information about PrEP and its availability; correct PrEP misconceptions and negative stereotypes; endorse PrEP use and its benefits; and strengthen friends' attitudes, intentions, perceived peer norms, and self-efficacy regarding PrEP as a personal HIV protective strategy.
Participants will receive brief (15-minute) counseling on how to prevent HIV infection.
Eligibility Criteria
You may qualify if:
- INDIVIDUALS:
- Age 16 or older
- For the seed only, self-report of HIV-negative serostatus or unknown serostatus
- Except for the seed, being named as a friend by an already-enrolled participant
- Male at birth
- Sex with at least one male partner in the past 12 months
- NETWORKS
- More than 49% of the seed's eligible friends agree to participate
- More than 49% of all network members self-report they are HIV-negative at baseline
You may not qualify if:
- INDIVIDUALS:
- Age 15 or younger
- For the seed only, self-report of HIV-positive serostatus
- Except for the seed, not being named as a friend by an already-enrolled participant
- Not male at birth
- No report of sex with at least one male partner in the past 12 months
- NETWORKS
- Less than 50% of the seed's eligible friends agree to participate
- Less than 50% of all network members self-report they are HIV-negative at baseline
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
AIDS TaskForce of Greater Cleveland
Cleveland, Ohio, 44113, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53202, United States
Related Publications (3)
Kelly JA. Ten Things We Need to Do to Achieve the Goals of the End the HIV Epidemic Plan for America. J Acquir Immune Defic Syndr. 2019 Dec 1;82 Suppl 2(2):S94-S98. doi: 10.1097/QAI.0000000000002166.
PMID: 31658194RESULTQuinn KG, Christenson E, Spector A, Amirkhanian Y, Kelly JA. The Influence of Peers on PrEP Perceptions and Use Among Young Black Gay, Bisexual, and Other Men Who Have Sex with Men: A Qualitative Examination. Arch Sex Behav. 2020 Aug;49(6):2129-2143. doi: 10.1007/s10508-019-01593-x. Epub 2020 Feb 3.
PMID: 32016815RESULTKelly JA, Amirkhanian YA, Walsh JL, Brown KD, Quinn KG, Petroll AE, Pearson BM, Rosado AN, Ertl T. Social network intervention to increase pre-exposure prophylaxis (PrEP) awareness, interest, and use among African American men who have sex with men. AIDS Care. 2020 May;32(sup2):40-46. doi: 10.1080/09540121.2020.1739207. Epub 2020 Mar 13.
PMID: 32167374RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeffrey A. Kelly, PhD
Medical College of Wisconsin
- PRINCIPAL INVESTIGATOR
Yuri A. Amirkhanian, PhD
Medical College of Wisconsin
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
January 24, 2019
First Posted
January 30, 2019
Study Start
January 24, 2019
Primary Completion
April 22, 2024
Study Completion
December 1, 2025
Last Updated
February 19, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will not share