Fibroblast Growth Factor 23 and Hypertensive Disorder Complicating Pregnancy

NCT03821922 | Unknown DMC

• 1 other identifier: FGF23
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertensive disorder complicating pregnancy is a set of diseases of pregnancy coexisting with elevated blood pressure. The incidence of it is approximately 5-12%. Pregnancy-induced hypertension is a pregnancy-specific disorder, severely impairing both maternal and fetal health, and the major cause of maternal and perinatal mortality rate increased. But so far, the specific etiology is still unclear. Recently, fibroblast growth factor 23 (FGF23) has emerged as key endocrine regulators of the metabolism of vitamin D and calcium and phosphorus by combining FGFR-α- Klotho receptor complex. Current studies showed that α- Klotho involved the development of gestational hypertension via the production of endothelial nitric oxide, angiogenesis, and the formation of antioxidant enzymes. On the other hand, vitamin D deficiency during pregnancy has an adverse impact on maternal and fetal health, including gestational hypertension. Therefore, the relationship of the expression of FGF23 and the development of gestational hypertension has attracted the attention of relevant scholars. The aim of this study is to detect the difference of the expression of FGF23 between the hypertensive women and normal pregnant women.

Conditions

Hypertension, Pregnancy-Induced

Keywords

Hypertension, Pregnancy-Induced; FGF23

Outcome Measures

Primary Outcomes (3)

• Expression of FGF23

  expression of FGF23 in different groups in mmol/l

  up to 14 weeks

• Expression of FGF23

  expression of FGF23 in different groups in mmol/l

  up to 28 weeks

• Expression of FGF23

  expression of FGF23 in different groups in mmol/l

  up to 40 weeks

Study Arms (2)

pregnancy-induced pregnancy

Those women (subjects) with pregnancy-induced pregnancy.

Control

Those healthy pregnant women

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

university hospital

You may qualify if:

• Women with singleton pregnancy;
• Regular antenatal examination from the first trimester;
• Give birth in the university hospital (The 1st affiliated hospital of Sun Yat-sen University)

You may not qualify if:

• Younger than 18 years old;
• Older than 40 years old;
• Multiple pregnancy;
• Complicated with other diseases such as hypertension, eclampsia, thyroid diseases, etc.

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

Obstetrics and Gynechology Department of the 1st affiliated hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510080, China

RECRUITING

MeSH Terms

Conditions

Hypertension, Pregnancy-Induced

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Zilian Wang, M.D,PhD

  O&G Department of the 1st affiliated hospital of Sun Yat-sen University

  STUDY DIRECTOR

Central Study Contacts

Dongyu Wang, M.D,PhD

CONTACT

86-020-87755766; dongyugd@aliyun.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 23, 2019
• First Posted: January 30, 2019
• Study Start: December 1, 2017
• Primary Completion: December 30, 2023
• Study Completion: December 31, 2023
• Last Updated: July 24, 2023

Record last verified: 2023-07

Locations

CN (1)