Registry Study for the Observation of Patients With ESUS/Cryptogenic Stroke
Catch-up-ESUS
1 other identifier
observational
750
1 country
1
Brief Summary
Up to know, there is no clear diagnostic and therapeutic pathway for patients with embolic stroke of undetermined source (ESUS). This prospective registry study, which follows up adult ESUS patients for 36 months, is intended to provide important data for the detection of an individual approach in ESUS patients based on a structured diagnostic and therapeutic pathway.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2018
CompletedFirst Submitted
Initial submission to the registry
January 14, 2019
CompletedFirst Posted
Study publicly available on registry
January 29, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2026
CompletedJanuary 30, 2019
January 1, 2019
5 years
January 14, 2019
January 28, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Recurrence of stroke
Detection of recurrence of ischemia in CT or MRT imaging due to new clinical symptoms
36 months
Secondary Outcomes (5)
Atrial fibrillation detection
36 months
Frequency of other vascular events depending on therapy (e.g. myocardial infarction, vascular death)
36 months
periprocedural events through PFO closure
36 months
Detection of predictors of recurrence of stroke
36 months
Collection of predictors for the appearance of atrial fibrillation
36 months
Eligibility Criteria
All patients (≥18 years) treated in our hospital and diagnosed with an ESUS will be collected. An extension to additional centres is planned in the course of the project, if good feasibility can be demonstrated.
You may qualify if:
- Embolic stroke of undetermined source or cryptogenic stroke; defined as: non-lacunar brain infarction without proximal arterial stenosis or cardioembolic source or other etiology (e.g. vasculitis, cervical artery dissection)
- ≥18 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ludwig Maximilians University
Munich, 80539, Germany
Related Publications (1)
Feil K, Heinrich J, Kupper C, Muller K, Laub C, von Falkenhausen AS, Becker R, Wollenweber FA, Kaab S, Sinner MF, Kellert L. Catch-up-ESUS - follow-up in embolic stroke of undetermined source (ESUS) in a prospective, open-label, observational study: study protocol and initial baseline data. BMJ Open. 2019 Dec 9;9(12):e031716. doi: 10.1136/bmjopen-2019-031716.
PMID: 31822542DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lars Kellert
Ludwig-Maximilians - University of Munich
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 36 Months
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
January 14, 2019
First Posted
January 29, 2019
Study Start
January 1, 2018
Primary Completion
January 1, 2023
Study Completion
January 1, 2026
Last Updated
January 30, 2019
Record last verified: 2019-01
Data Sharing
- IPD Sharing
- Will not share