A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort

NCT03814837 | Unknown DMC

• 1 other identifier: UUH 2017-06-012-001
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

TOXOCARA Study is a prospective observational cohort study. The aim of this study is to evaluate the incidence of ocular toxocariasis (OT) associated with pulmonary toxocariasis (PT) in patients with chest diagnostic image tests (chest X-ray, chest CT) with migrating ground glass opacity or nodular lesions. Also a cohort study is to track the results of treatment for diagnosed ocular toxocariasis (OT) patients.

Conditions

Toxocariasis; Ocular Toxocariasis; Pulmonary Toxocariasis; Ground Glass Opacity (GGO); Toxocara Canis Infection (Canine Roundworms); Law Liver; Law Meat; Serum Toxocara Antibody; Toxocara Larva Migrans

Outcome Measures

Primary Outcomes (3)

• Number of patients with pulmonary toxocariasis (PT)

  Patients who have a positive result of serum toxocara Ab and migrating pulmonary GGOs or nodular lesions and history of eating of law animal liver or meat or history of having the pets such as dogs and cats.

  at baseline

• Number of patients with ocular toxocariasis (OT)

  Patients who have the clinical manifestation of intraocular infection by Toxocara larvae and a positive result of serum toxocara Ab and history of eating of law animal liver or meat. (and/or migrating pulmonary GGOs or nodular lesions) or history of having the pets such as dogs and cats.

  at baseline

• Number of patients with ocular toxocariasis (OT) among the patients with pulmonary toxocariasis (PT),

  Patients who have ocular toxocariasis (OT) with pulmonary toxocariasis (PT)

  at baseline

Secondary Outcomes (6)

• Incidence of Cysticercosis

  at baseline

• Incidence of Sparganosis

  at baseline

• Incidence of Clonorchiasis

  at baseline

• Incidence of Paragonimiasis

  at baseline

• Incidence of Anisakiasis

  at baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The investigators defined pulmonary toxocariasis (PT) as a positive form of serum toxocara Ab and migrating pulmonary GGOs or nodular lesions. Ocular toxocariasis (OT) is defined by the clinical manifestation of intraocular infection by Toxocara larvae and a positive form of serum toxocara Ab.

You may qualify if:

• Aged 18 years and older
• Patient who has positive result of Toxocara Ab
• Patient who has history of eating of law animal liver or meat
• Patient who has the chest diagnostic image tests (chest X-ray, chest CT) with migrating ground glass opacity or nodular lesions.

You may not qualify if:

• Age \< 18 years
• Pregnant woman
• Malignant patient
• Patient who has pulmonary infectious lesion such as pneumonia, fungus and tuberculosis
• Patients who were diagnosed by benign or malignant pulmonary nodule
• Patient who was not consented

Sponsors & Collaborators

• University of Ulsan: lead
• Ulsan University Hospital: collaborator

Study Sites (1)

Ulsan University Hospital, 877 Bangeojin Sunwhando-ro

Ulsan, 44033, South Korea

RECRUITING

MeSH Terms

Conditions

Toxocariasis; Larva Migrans; Toxocara canis infection (canine roundworms)

Condition Hierarchy (Ancestors)

Helminthiasis, Animal; Helminthiasis; Parasitic Diseases; Infections; Ascaridida Infections; Secernentea Infections; Nematode Infections; Parasitic Diseases, Animal; Animal Diseases; Skin Diseases, Parasitic; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Kwang Won Seo, M.D.

  Ulsan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kwang Won Seo, M.D.

CONTACT

+82-10-9709-9138; kwseo@uuh.ulsan.kr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, division of pulmonology, dept. of internal medicine

Study Record Dates

• First Submitted: January 9, 2019
• First Posted: January 24, 2019
• Study Start: July 10, 2017
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: January 24, 2019

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)