The Therapeutic Effect of Exercise Training on Patients With Dementia and Mild Cognitive Impairment

NCT03811314 | Completed

• 1 other identifier: CF18010B
• Study Type: interventional
• Target: 107
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment

Conditions

Dementia

Keywords

Dementia

Outcome Measures

Primary Outcomes (6)

• Barthel index

  To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome

  4 weeks

• Mini-mental state examination

  To evaluate cognitive function, range from 0-30, higher values represent a better outcome

  4 weeks

• Montreal Cognitive Assessment

  To evaluate cognitive function, range from 0-30, higher values represent a better outcome

  4 weeks

• Geriatric Depression Scale

  To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome

  4 weeks

• Timed up and go test

  Measure the time taken by a patient to stand up from a chair, walk three meters, return, and sit back on the chair

  4 weeks

• SF-36

  consists of 36 questions categorized into 8 subdomains, including physical functioning, role limitations due to physical health, pain, general health condition, vitality, social functioning, role limitations due to emotional problems, and emotional well-being.

  4 weeks

Secondary Outcomes (3)

• Concentration of serum brain derived neurotrophic factor (BDNF)

  4 weeks

• Concentration of plasma insulin-like growth factor-1 (IGF-1)

  4 weeks

• Concentration of plasmamonocyte chemotactic protein-1 (MCP-1)

  4 weeks

Study Arms (4)

Strength training

EXPERIMENTAL

Muscle strength training programs

Device: Strength training

Aerobic training

EXPERIMENTAL

Aerobic training programs

Device: Aerobic training

Isokinetic training

EXPERIMENTAL

Isokinetic training

Device: Isokinetic trinaing

Isotonic training

EXPERIMENTAL

Isotonic training

Device: Isotonic training

Interventions

Strength training DEVICE

Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks

Strength training

Aerobic training DEVICE

Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks

Aerobic training

Isokinetic trinaing DEVICE

Using Biodex isokinetic dynanometer and set it in isokinetic mode in 60 degree per second

Isokinetic training

Isotonic training DEVICE

Using Biodex isokinetic dynanometer and set it in isotonic mode at 60% of the maximal peak torque

Isotonic training

Eligibility Criteria

• Age: 40 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged above 65 years old
• Patients with mild dementia with Mini-mental state examination scoring 15 to 26
• Another arm is patients with mild cognitive impairment and Mini-mental state examination scoring 23 to 27

You may not qualify if:

• Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs
• Cognitive problems that impede the patient to understand and answer the content of our questionnaires.

Sponsors & Collaborators

• Taichung Veterans General Hospital: lead

Study Sites (1)

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

Location

Related Publications (1)

• Liu IT, Lee WJ, Lin SY, Chang ST, Kao CL, Cheng YY. Therapeutic Effects of Exercise Training on Elderly Patients With Dementia: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 May;101(5):762-769. doi: 10.1016/j.apmr.2020.01.012. Epub 2020 Feb 19.

  PMID: 32084347 DERIVED

MeSH Terms

Conditions

Dementia

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Yuan-Yang Cheng, MDPHD

  Department of rehabilitation of Taichung Veterans General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: comparison of therapeutic effect between aerobic and strength training on dementia patient, and comparison of therapeutic effect between isokinetic and isotonic training on patients with mild cognitive impairment

Study Record Dates

• First Submitted: January 13, 2019
• First Posted: January 22, 2019
• Study Start: April 9, 2018
• Primary Completion: December 26, 2023
• Study Completion: December 26, 2023
• Last Updated: February 28, 2024

Record last verified: 2024-02

Locations

TW (1)