Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients

NCT03807453 | Completed

• 1 other identifier: IstanbulMU2
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

Conditions

Psoriasis Vulgaris; Seborrheic Dermatitis; Microbial Colonization

Keywords

Psoriasis Vulgaris; Seborrheic Dermatitis; Scalp; Microbiome

Outcome Measures

Primary Outcomes (1)

• The scalp microbiota of the patients with psoriasis and seborrheic dermatitis

  The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment. The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.

  6 months

Secondary Outcomes (1)

• The differences between the scalp microbiota of different countries

  6 months

Study Arms (5)

Psoriasis Vulgaris patients-Lesion

Other: Microbiota

Psoriasis Vulgaris patients-Lesion free

Other: Microbiota

Seborrheic Dermatitis-Lesion

Other: Microbiota

Seborrheic Dermatitis-Lesion free

Other: Microbiota

Control Group

Other: Microbiota

Interventions

Microbiota OTHER

The scalp microbiota

Control Group; Psoriasis Vulgaris patients-Lesion; Psoriasis Vulgaris patients-Lesion free; Seborrheic Dermatitis-Lesion; Seborrheic Dermatitis-Lesion free

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

primary care clinic and community sample

You may qualify if:

• Patients with scalp psoriasis
• Patients with seborrheic dermatitis
• Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months

You may not qualify if:

• Patients who do not want to participate in the study
• Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
• Those with chronic diseases that may affect skin microbiome
• Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
• Patients who are using topical or systemic drugs for their illness

Sponsors & Collaborators

• Istanbul Medeniyet University: lead
• Turkish Dermatology Association: collaborator

Study Sites (1)

Melek Aslan Kayıran

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Dermatitis, Seborrheic; Communicable Diseases

Interventions

Microbiota

Condition Hierarchy (Ancestors)

Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Sebaceous Gland Diseases; Skin Diseases, Eczematous; Skin Diseases, Papulosquamous; Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Microbiological Phenomena; Biota; Biodiversity; Ecosystem; Environment; Ecological and Environmental Phenomena; Biological Phenomena; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dermatologist, M.D.

Study Record Dates

• First Submitted: January 5, 2019
• First Posted: January 17, 2019
• Study Start: April 25, 2019
• Primary Completion: June 18, 2019
• Study Completion: June 18, 2019
• Last Updated: September 10, 2020

Record last verified: 2020-09

Locations

TU (1)