NCT03806439

Brief Summary

Post-surgical delirium in patients undergoing radical cystectomy. Introduction Delirium occurs after major abdominal surgery may reach about 15% of the patients.(1) Aim The aim of this study is to determine the incidence of delirium after radical cystectomy surgery and the associated risk factors in Alexandria University hospital. Patients and Methods After approval of local ethical committee and patient consent, the study will be done on patients undergoing radical cystectomy surgery in Alexandria University hospitals from January 5th 2019 till January 4th 2020. The 6-item Cognitive Impairment Test (6CIT) and SPMSQ questionnaire will be used. SPMSQ will be done preoperative and daily for 3 days postoperative, at day 7. Phone call for SPMSQ will be done 3, 6, 9 and 12 months after surgery.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
12mo left

Started Nov 2028

Shorter than P25 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 5, 2019

Completed
11 days until next milestone

First Posted

Study publicly available on registry

January 16, 2019

Completed
9.9 years until next milestone

Study Start

First participant enrolled

November 25, 2028

Expected
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 24, 2029

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 24, 2029

Last Updated

April 3, 2025

Status Verified

March 1, 2025

Enrollment Period

12 months

First QC Date

January 5, 2019

Last Update Submit

March 31, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Delirium

    Post-surgical delirium in patients undergoing radical cystectomy.

    1 year

Secondary Outcomes (1)

  • Mortality

    1 year

Study Arms (1)

Patients undergoing radical cystectomy.

After approval of local ethical committee and patient consent, the study will be done on patients undergoing radical cystectomy surgery in Alexandria University hospitals from January 5th 2019 till January 4th 2020. The 6-item Cognitive Impairment Test (6CIT) and SPMSQ questionnaire will be used. SPMSQ will be done preoperative and daily for 3 days postoperative, at day 7. Phone call for SPMSQ will be done 3, 6, 9 and 12 months after surgery.

Other: Radical cystectomy.

Interventions

Adult patients undergoing radical cystectomy.

Patients undergoing radical cystectomy.

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients undergoing radical cystectomy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Raats JW, van Eijsden WA, Crolla RM, Steyerberg EW, van der Laan L. Risk Factors and Outcomes for Postoperative Delirium after Major Surgery in Elderly Patients. PLoS One. 2015 Aug 20;10(8):e0136071. doi: 10.1371/journal.pone.0136071. eCollection 2015.

MeSH Terms

Conditions

Delirium

Interventions

Cystectomy

Condition Hierarchy (Ancestors)

ConfusionNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Urologic Surgical ProceduresUrogenital Surgical ProceduresSurgical Procedures, Operative

Study Officials

  • Mohammad Hazem I Ahmad Sabry, MB,ChB MD

    Alexandria University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohammad Hazem I Ahmad Sabry, MB,ChB

CONTACT

Mohammad Hazem I Sabry

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Target Duration
12 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer of Anesthesia

Study Record Dates

First Submitted

January 5, 2019

First Posted

January 16, 2019

Study Start (Estimated)

November 25, 2028

Primary Completion (Estimated)

November 24, 2029

Study Completion (Estimated)

November 24, 2029

Last Updated

April 3, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will not share