Magnetic Resonance Imaging (MRI) of Pulp Regeneration
Magnetic Resonance Imaging Assessment of Pulp Regeneration Following Regenerative Endodontic Procedures in Mature Teeth
1 other identifier
interventional
18
1 country
1
Brief Summary
The present study was conducted to test whether pulp-like tissue can be regenerated in mature teeth with closed apex? And whether the size of the apical diameter affects the success of REPs? And whether Magnetic resonance imaging (MRI) can be used to quantitatively assess the vitality of the regenerated pulp-like tissue.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Jul 2017
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 3, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 28, 2018
CompletedFirst Submitted
Initial submission to the registry
January 7, 2019
CompletedFirst Posted
Study publicly available on registry
January 15, 2019
CompletedJanuary 17, 2019
January 1, 2019
1.2 years
January 7, 2019
January 15, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
MRI assessment of pulp-like tissue regeneration
Signal intensity of the regenerated pulp-like tissue was quantitatively measured in both test and control groups after 3,6 and 12 months follow up and compared to the contralateral normal teeth.
12 months
Secondary Outcomes (2)
Healing of the periapical lesion
12 months
Positive pulpal response
12 months
Study Arms (2)
Test group
EXPERIMENTALThe root canals were instrumented using Pro-taper next rotary files till size X3. REPs via blood clot using calcium hydroxide were then applied
Control group
EXPERIMENTALThe root canals were instrumented using Pro-taper next rotary files till size X5. REPs via blood clot using calcium hydroxide were then applied.
Interventions
Instrumentation using rotary Pro-Taper Next, disinfection using sodium hypochlorite and calcium hydroxide as intracanal medication followed by induction of blood and application of Biodentine as a cervical plug.
Eligibility Criteria
You may qualify if:
- Upper anterior mature teeth with single canals.
- Necrotic teeth
- Presence of periapical lesion.
You may not qualify if:
- Presence of systemic diseases.
- Presence of stainless steel wires o brackets
- Vital immature teeth with open apex
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Alexandria University
Alexandria, Egypt
Related Publications (1)
El-Kateb NM, Abdallah AM, ElBackly RN. Correlation between pulp sensibility and magnetic resonance signal intensity following regenerative endodontic procedures in mature necrotic teeth- a retrospective cohort study. BMC Oral Health. 2024 Mar 13;24(1):330. doi: 10.1186/s12903-024-04095-y.
PMID: 38481211DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant lecturer, Faculty of dentistry
Study Record Dates
First Submitted
January 7, 2019
First Posted
January 15, 2019
Study Start
July 1, 2017
Primary Completion
September 3, 2018
Study Completion
December 28, 2018
Last Updated
January 17, 2019
Record last verified: 2019-01