Effect of Vitamin D on Outcome of Assisted Reproductive Technology(ART);
ART
1 other identifier
observational
4,000
1 country
1
Brief Summary
Vitamin D has many biological functions. Vitamin D receptors are widely distributed in the male and female reproductive system. Animal experiments have shown that vitamin D deficiency can affect hormone synthesis and gamete formation, reduce sperm motility, and may be related to diseases such as PCOS and endometriosis. Population studies suggest that vitamin D may be related to androgen levels and sperm quality, but whether vitamin D affects the outcome of assisted reproduction is controversial and inconclusive. This study intends to explore whether vitamin D affects the outcome of assisted reproduction through a large sample cohort study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 28, 2018
CompletedFirst Submitted
Initial submission to the registry
January 11, 2019
CompletedFirst Posted
Study publicly available on registry
January 15, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2020
CompletedJanuary 17, 2019
January 1, 2019
1 year
January 11, 2019
January 15, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
clinical pregnancy rates
Time Frame: the presence of an intrauterinesac with an embryonic pole demonstrating cardiacactivity
12 weeks after transplantation
Study Arms (1)
vitamin D-ART
Infertile couples who undergo their first IVF/ICSI and IUI cycle in Reproductive Medicin Center of Peking university Third Hosiptal.
Eligibility Criteria
infertile couples
You may qualify if:
- infertile couples who undergo their first IVF/ICSI and IUI cycle at Reproductive Medicine Center of Peking University Third Hospital.
You may not qualify if:
- refusing to be recruited.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking University Third Hospital
Beijing, Beijing Municipality, 100091, China
Related Publications (1)
Chen Y, Liu D, Zeng L, Xu H, Jiang H, Yang R, Wang H, Yan L, Li R, Qiao J, Zhi X. Effect of serum 25-hydroxyvitamin D levels on sperm quality and assisted reproductive technology outcomes for men of infertile Chinese couples. Andrology. 2020 Sep;8(5):1277-1286. doi: 10.1111/andr.12818. Epub 2020 Jun 3.
PMID: 32412142DERIVED
Biospecimen
serum
Study Officials
- STUDY CHAIR
XU ZHI
Peking University Third Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- associate professor
Study Record Dates
First Submitted
January 11, 2019
First Posted
January 15, 2019
Study Start
November 28, 2018
Primary Completion
December 1, 2019
Study Completion
July 1, 2020
Last Updated
January 17, 2019
Record last verified: 2019-01