NCT03803280

Brief Summary

The main objective is the multicenter and uniform implementation of a agreed upon perioperative evidence based program emanated from the Enhanced Recovery for abdominal surgery pathway (RICA) published by the Spanish National Health Service and the Aragon Institute of Health, in hospitals of the National Health Network. The evaluation and outcomes of such implementation is proposed as a secondary objective. Different established indicator will compared traditional care results with those from the new program in the short and medium term. 10 interested hospital centers are selected. In each of them a retrospective study will be conducted to analyze the clinical results obtained in abdominal surgery in the past six months. After making the necessary training to clinical teams and assure the project development and implementation in each center, a prospective study in which all patients in the program are being recruited will be held. Hospital stay as well as perioperative mortality and morbidity will be collected. We will analyze data from: days of hospital stay (potential and actual), efficiency (cost/procedure), quality of care, time to complete reintegration into family, social and labor environment and quality of life.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2016

Longer than P75 for all trials

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 15, 2016

Completed
2.5 years until next milestone

First Submitted

Initial submission to the registry

January 11, 2019

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 14, 2019

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2022

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

January 14, 2022

Status Verified

January 1, 2022

Enrollment Period

6 years

First QC Date

January 11, 2019

Last Update Submit

January 13, 2022

Conditions

Major Surgery

Outcome Measures

Primary Outcomes (3)

  • Number of patients with postoperative complications

    complications after surgery

    30 days after surgery

  • Mortality

    Number of patients dead after surgery

    3 years

  • Long term mortality

    Number of patients dead after surgery

    5 years

Secondary Outcomes (4)

  • Hospital stay

    perioperative stay

  • compliance of the protocol

    1 month after surgery

  • re-admission

    1 month after surgery

  • Cost

    1 month after surgery

Study Arms (2)

Traditional care

Patients with major abdominal surgery without before a enhanced recovery program was stablished

ERAS care

Patients with major abdominal surgery within a enhanced recovery program was stablished

Procedure: ERAS program

Interventions

ERAS programPROCEDURE

ERAS pathway according to the Spanish Via RICA

ERAS care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients over 18 years old, scheduled for major abdominal surgical surgery, due to malignant or benign causes (It is defined as complex major surgery that lasts more than two hours or it is estimated that it may require the transfusion of at least 2 red cell concentrates or it is estimated a loss greater than or equal to 15% of the patient's blood volumen).

You may qualify if:

  • Patients over 18 years old, scheduled for major abdominal surgical surgery, due to malignant or benign causes.

You may not qualify if:

  • Urgent Surgery.
  • Patients ASA (American Society of Anesthesiology) IV or higher.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Hospital Universitario Infanta Leonor

Madrid, Spain

RECRUITING

Complejo Hospitalario de Salamanca

Salamanca, Spain

RECRUITING

Hospital Clínico Universitario Lozano Blesa

Zaragoza, Spain

RECRUITING

Related Publications (12)

  • Vorwald P, Bruna Esteban M, Ortega Lucea S, Ramirez Rodriguez JM; Grupo de Trabajo de Cirugia Esofagogastrica del Grupo Espanol de Rehabilitacion Multimodal (GERM). Enhanced recovery after esophageal resection. Cir Esp (Engl Ed). 2018 Aug-Sep;96(7):401-409. doi: 10.1016/j.ciresp.2018.02.010. Epub 2018 Mar 21. English, Spanish.

    PMID: 29573788RESULT

  • Bruna M, Navarro C, Baez C, Ramirez JM, Ortiz MA. Results of a national survey about perioperative care in gastric resection surgery. Cir Esp (Engl Ed). 2018 Aug-Sep;96(7):410-418. doi: 10.1016/j.ciresp.2018.03.004. Epub 2018 Apr 24. English, Spanish.

    PMID: 29699695RESULT

  • Ruiz-Tovar J, Munoz JL, Royo P, Duran M, Redondo E, Ramirez JM; Grupo Espanol de Rehabilitacion Multimodal (GERM). Implementation of the Spanish ERAS program in bariatric surgery. Minim Invasive Ther Allied Technol. 2018 Dec;27(6):365-372. doi: 10.1080/13645706.2018.1446988. Epub 2018 Mar 8.

    PMID: 29519184RESULT

  • Bruna Esteban M, Vorwald P, Ortega Lucea S, Ramirez Rodriguez JM; Grupo de Trabajo de Cirugia Esofagogastrica del Grupo Espanol de Rehabilitacion Multimodal (GERM). Enhanced recovery after surgery in gastric resections. Cir Esp. 2017 Feb;95(2):73-82. doi: 10.1016/j.ciresp.2016.10.013. Epub 2017 Feb 6. English, Spanish.

    PMID: 28185641RESULT

  • Martinez AB, Longas J, Ramirez JM. A model for lymphocyte activation in open versus laparoscopic surgery in colorectal cancer patients in enhanced recovery after surgery (ERAS) protocols. Int J Colorectal Dis. 2017 Jun;32(6):913-916. doi: 10.1007/s00384-016-2731-2. Epub 2016 Nov 30.

    PMID: 27900463RESULT

  • Ruiz-Tovar J, Royo P, Munoz JL, Duran M, Redondo E, Ramirez JM; GERM. Implementation of the Spanish National Enhanced Recovery Program (ERAS) in Bariatric Surgery: A Pilot Study. Surg Laparosc Endosc Percutan Tech. 2016 Dec;26(6):439-443. doi: 10.1097/SLE.0000000000000323.

    PMID: 27753710RESULT

  • Moya P, Soriano-Irigaray L, Ramirez JM, Garcea A, Blasco O, Blanco FJ, Brugiotti C, Miranda E, Arroyo A. Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study). Medicine (Baltimore). 2016 May;95(21):e3704. doi: 10.1097/MD.0000000000003704.

    PMID: 27227930RESULT

  • Gonzalez-Ayora S, Pastor C, Guadalajara H, Ramirez JM, Royo P, Redondo E, Arroyo A, Moya P, Garcia-Olmo D. Enhanced recovery care after colorectal surgery in elderly patients. Compliance and outcomes of a multicenter study from the Spanish working group on ERAS. Int J Colorectal Dis. 2016 Sep;31(9):1625-31. doi: 10.1007/s00384-016-2621-7. Epub 2016 Jul 4.

    PMID: 27378580RESULT

  • Esteban F, Cerdan FJ, Garcia-Alonso M, Sanz-Lopez R, Arroyo A, Ramirez JM, Moreno C, Morales R, Navarro A, Fuentes M. A multicentre comparison of a fast track or conventional postoperative protocol following laparoscopic or open elective surgery for colorectal cancer surgery. Colorectal Dis. 2014 Feb;16(2):134-40. doi: 10.1111/codi.12472.

    PMID: 24164975RESULT

  • Nygren J, Thacker J, Carli F, Fearon KC, Norderval S, Lobo DN, Ljungqvist O, Soop M, Ramirez J; Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care; European Society for Clinical Nutrition and Metabolism (ESPEN); International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS((R))) Society recommendations. World J Surg. 2013 Feb;37(2):285-305. doi: 10.1007/s00268-012-1787-6. No abstract available.

    PMID: 23052796RESULT

  • Arroyo A, Ramirez JM, Callejo D, Vinas X, Maeso S, Cabezali R, Miranda E; Spanish Working Group in Fast Track Surgery (GERM). Influence of size and complexity of the hospitals in an enhanced recovery programme for colorectal resection. Int J Colorectal Dis. 2012 Dec;27(12):1637-44. doi: 10.1007/s00384-012-1497-4. Epub 2012 May 27.

    PMID: 22645075RESULT

  • Ramirez JM, Blasco JA, Roig JV, Maeso-Martinez S, Casal JE, Esteban F, Lic DC; Spanish working group on fast track surgery. Enhanced recovery in colorectal surgery: a multicentre study. BMC Surg. 2011 Apr 14;11:9. doi: 10.1186/1471-2482-11-9.

    PMID: 21489315RESULT

Study Officials

  • Jose M Calvo, Dr

    Grupo Español de Rehabilitación Multimodal

    STUDY CHAIR

Central Study Contacts

Jose M Ramirez, Prof

CONTACT

+34 639776364jramirez@unizar.es

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 11, 2019

First Posted

January 14, 2019

Study Start

July 15, 2016

Primary Completion

July 31, 2022

Study Completion

December 31, 2022

Last Updated

January 14, 2022

Record last verified: 2022-01

Locations

ES(3)