Crosslinking in Infectious Keratitis
Safety and Efficacy Of Corneal Collagen Crosslinking (CXL) In Infectious Keratitis
1 other identifier
interventional
20
0 countries
N/A
Brief Summary
Microbial keratitis is an infection of the cornea that is associated with risk of permanent visual impairment. It can be caused by bacteria, virus, fungus, protozoa and parasites. The common risk factors for infectious keratitis include ocular trauma, contact lens wear, recent ocular surgery, preexisting ocular surface disease, dry eyes, lid deformity, corneal sensation impairment, chronic use of topical steroids and systemic immunosuppression .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Dec 2021
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 7, 2019
CompletedFirst Posted
Study publicly available on registry
January 11, 2019
CompletedStudy Start
First participant enrolled
December 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2023
CompletedJuly 20, 2021
July 1, 2021
1 month
January 7, 2019
July 19, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Determine the duration for corneal ulcer healing
By follow up with photography before crosslinking and one week after performing cxl.
one year
Study Arms (1)
CXL on patients with infectious keratitis
EXPERIMENTALthe procedure of cross linking(CXL) :combined riboflavin-ultraviolet type A rays (UVA) collagen cross-linking. Radiant energy was 3 milliwatts/cm2 for a 30-minute exposure irradiation of the cornea will be carried out on twenty patients with infectious keratitis .
Interventions
the procedure of cross linking(CXL) :combined riboflavin-ultraviolet type A rays (UVA) collagen cross-linking. Radiant energy was 3 milliwatts/cm2 for a 30-minute exposure irradiation of the cornea.
Eligibility Criteria
You may qualify if:
- Patients with proved bacterial, fungal, acanthamoeba microbial keratitis .
- Patient willing to comply with all study procedures .
You may not qualify if:
- Severe corneal scarring or opacification .
- Patients with viral infectious keratitis
- Prior herpetic infections .
- Patients with any coexisting ocular pathology,ocular surface disease .
- Patients with Autoimmune disease.
- Pregnant women .
- Corneal Thickness of less than 400 microns .
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Green M, Apel A, Stapleton F. Risk factors and causative organisms in microbial keratitis. Cornea. 2008 Jan;27(1):22-7. doi: 10.1097/ICO.0b013e318156caf2.
PMID: 18245962BACKGROUNDJankov Ii MR, Jovanovic V, Nikolic L, Lake JC, Kymionis G, Coskunseven E. Corneal collagen cross-linking. Middle East Afr J Ophthalmol. 2010 Jan;17(1):21-7. doi: 10.4103/0974-9233.61213.
PMID: 20543933BACKGROUND
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
January 7, 2019
First Posted
January 11, 2019
Study Start
December 1, 2021
Primary Completion
January 1, 2022
Study Completion
January 1, 2023
Last Updated
July 20, 2021
Record last verified: 2021-07