NCT03799029

Brief Summary

This study examines the impact of cognitive training among participants with ADHD in Switzerland

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
240

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Feb 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 28, 2018

Completed
8 months until next milestone

First Posted

Study publicly available on registry

January 10, 2019

Completed
1 month until next milestone

Study Start

First participant enrolled

February 20, 2019

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2021

Completed
2.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2023

Completed
Last Updated

January 10, 2019

Status Verified

January 1, 2019

Enrollment Period

2.3 years

First QC Date

May 28, 2018

Last Update Submit

January 7, 2019

Conditions

Keywords

Cognitive trainingtreatmentADHD

Outcome Measures

Primary Outcomes (2)

  • ADHD symptoms for adults

    The Conners' Adult ADHD Rating Scales (CAARS) higher values represent worse outcome The Conners' Adult ADHD Rating Scales (CAARS) is used to assess ADHD symptoms among adults (Conners et al., 1999) depending on the DSM-IV-TR (APA, 2000). This short version includes 26 items and 4 possible ratings from from 0 (not at all) to 3 (very much). This scale comprises four factors: (1) inattention, memory problems, (2) hyperactivity, restlessness, (3) impulsivity, emotional lability, (4) problems with self-concept and one ADHD index. score are summed. Range 0 to 100.

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

  • ADHD symptoms for children

    The Conners Scale, 3rd edition higher values represent a worse outcome Questionnaire is rated by the legal guardian. This questionnaire assesses ADHD symptoms.Score are summed. Score range 0 to 100.

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

Secondary Outcomes (7)

  • Impulsivity

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

  • executive function

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

  • Reward

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

  • Reward

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4

  • Memory

    Change between two time points from baseline T1 to six week later T2 after cognitive training is assessed. Follow up is assessed at 3 months T3 and 6 months T4 training 4. Six months after cognitive training

  • +2 more secondary outcomes

Study Arms (3)

active control group low-intensity

ACTIVE COMPARATOR

Low intensity version of the same cognitive training program Exercice are realized at home using a computer 25 sessions of 30-45 minutes are realized five days per week during 5 weeks

Other: Cognitive training

experimental training group cognitive training

EXPERIMENTAL

a multifactorial cognitive program that tackles working memory, attention, inhibition, planification and reasoning Exercice are realized at home using a computer 25 sessions of 30-45 minutes are realized five days per week during 5 weeks

Other: Cognitive training

control healthy participants

NO INTERVENTION

Just a control group including healthy participants No intervention

Interventions

Participants will train at home during 25 sessions (about 45 minutes each) over a maximum of 5 weeks. Investigators will verify compliance via Internet and call participants and their legal guardians once a week. A reward system will be established with participants. Five sessions of metacognition (1 hour each) are added.

active control group low-intensityexperimental training group cognitive training

Eligibility Criteria

Age6 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Age between 6 and 65 years' old
  • ADHD diagnostic by a specialist
  • IQ-score higher than 80 for adult according to (WAIS-IV; Wechsler, 2008) and for children and adolescents according to (WISC-IV; Wechsler, 2003)
  • Treatment with or without medication for ADHD
  • Computer and Internet connexion at home
  • Informed consent from participants and the legal guardian of the minors (under 14 years old) involved - as documented by signature (Appendix Informed Consent Form).
  • Age between 6 and 65 years' old
  • No ADHD diagnostic by a specialist
  • IQ-score higher than 80 for adult according to (WAIS-IV; Wechsler, 2008) and for children and adolescents according to (WISC-IV; Wechsler, 2003)
  • No medication treatment for ADHD
  • Informed consent from participants and the legal guardian of the minors involved - as documented by signature (Appendix Informed Consent Form).

You may not qualify if:

  • Age younger than 6 and older than 65 years' old
  • No diagnosis of ADHD
  • IQ-score lower than 80 points according to (WAIS-IV; Wechsler, 2008) and for children and adolescents according to (WISC-IV; Wechsler, 2003)
  • No computer and Internet access at home
  • No written consent from participants and from the legal guardians of minors involved as less than 14 years old.
  • Age younger than 6 and older than 65 years' old
  • Diagnosis of ADHD or other mental disorders
  • IQ-score lower than 80 points according to (WAIS-IV; Wechsler, 2008) and for children and adolescents according to (WISC-IV; Wechsler, 2003)
  • No written consent from participants and from the legal guardians of minors involved (for participants under 14 years old)
  • In case of suicidal risk, the participant is encouraged to consult the medical staff.
  • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
  • Previous enrolment into the current study
  • Enrolment of the investigator, his/her family members, employees and other dependent persons

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dentz Amélie

Montreal, Quebec, 2000, Canada

Location

Related Publications (2)

  • Spencer-Smith M, Klingberg T. Correction: Benefits of a Working Memory Training Program for Inattention in Daily Life: A Systematic Review and Meta-Analysis. PLoS One. 2016 Nov 22;11(11):e0167373. doi: 10.1371/journal.pone.0167373. eCollection 2016.

    PMID: 27875585BACKGROUND
  • Gathercole SE. Commentary: Working memory training and ADHD - where does its potential lie? Reflections on Chacko et al. (2014). J Child Psychol Psychiatry. 2014 Mar;55(3):256-7. doi: 10.1111/jcpp.12196. Epub 2014 Jan 20.

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior DisordersNeurodevelopmental DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Neurological RehabilitationRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Amélie Dentz, Ph.D

    University of Fribourg

    PRINCIPAL INVESTIGATOR
  • Martin Soelch Chantal, PR

    University of Fribourg

    PRINCIPAL INVESTIGATOR

Central Study Contacts

amelie dentz, Ph.D

CONTACT

Chantal Martin Soelch, Pr

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Participant are blind on their group assignation. Investigator are blind on group assignation
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: will compare the ADHD group with a control group including healthy participants .The experimental study uses a pseudo-randomized, double-blind, controlled multi-center design.Participants will be assigned to an experimental group (cognitive training ) or in a control active group.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principal investigator Ph.D

Study Record Dates

First Submitted

May 28, 2018

First Posted

January 10, 2019

Study Start

February 20, 2019

Primary Completion

June 1, 2021

Study Completion

December 1, 2023

Last Updated

January 10, 2019

Record last verified: 2019-01

Data Sharing

IPD Sharing
Will not share

Locations