Peripheral Perfusion Index, Haemoglobin and Blood Transfusion in Acute Surgical Patients

NCT03795467 | Unknown

• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The peripheral perfusion index (PPI) is a non-invasive, feasible measure of peripheral perfusion and, assumed, the overall circulation, which all patients are monitored by. This study is carried out to assess the association between values of PPI, haemoglobin and blood transfusion. Hypothetically, patients with low values of hb are more susceptible to a deteriorating circulation reflected in poorer PPI regardless of blood pressure and that resuscitation with blood products improves PPI measurements. Moreover, that patients with low values of PPI have more surgical complications and higher mortality.

Conditions

Fracture of Hip; Ileus; Perforated Viscus; Anastomotic Leak

Outcome Measures

Primary Outcomes (2)

• Peripheral perfusion index

  Absolute PPI levels

  Perioperative with 5 minute interval

• Haemoglobin level

  Measurement of haemoglobin by blood sample or artery gas.

  Time interval: From 3 hours preoperative to 10 hours postoperative

Secondary Outcomes (3)

• Evaluation of Peripheral perfusion index in patients with high vs. low haemoglobin levels in relation to mean arterial blood pressure (MAP).

  Perioperative

• Proportion of transfusion with blood products in patients with perioperative high vs. low haemoglobin levels.

  Perioperative

• Evaluation of peripheral perfusion index changes in patients with perioperative high vs. low haemoglobin levels in relation to transfusion with blood products .

  Perioperative

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients \> 18 years of age having performed acute abdominal or orthopedic surgery from 1th November 2017 through 31th October 2018 at Hvidovre and Bispebjerg University Hospitals. Study subjects will be obtained from the hospitals electronic medical records via specific procedural- or diagnostic codes representing the acute orthopedic or abdominal surgery in the specified one-year period.

You may qualify if:

• Orthopedic surgery patients with fracture of the hip, booked in the electronic patient record for operation with procedural codes:KNFB02 HNFJ81 KNFJ51 KNFJ52 KNFJ70
• Acute abdominal surgery patients booked in the electronic patient record for operation with procedural codes:KJAH01 KJAH00

You may not qualify if:

• No sampling of PPI registered
• Foreign/temporary civil registration number
• Already included in cohort

Sponsors & Collaborators

• Hvidovre University Hospital: lead

Study Sites (1)

Department of Anesthesia, Hvidovre Hospital

Hvidovre, Copenhagen, 2650, Denmark

Location

Related Publications (1)

• Lau FF, Agerskov M, Thusholdt ANW, Hojlund J, Meyhoff CS, Jans O, Foss NB. Peripheral perfusion index stratifies risk in patients with intraoperative anemia: A multicentre cohort study. J Clin Anesth. 2024 Aug;95:111472. doi: 10.1016/j.jclinane.2024.111472. Epub 2024 Apr 12.

  PMID: 38613938 DERIVED

MeSH Terms

Conditions

Hip Fractures; Ileus; Anastomotic Leak

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Intestinal Obstruction; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Research Fellow

Study Record Dates

• First Submitted: January 2, 2019
• First Posted: January 7, 2019
• Study Start: November 1, 2017
• Primary Completion: October 31, 2018
• Study Completion: June 1, 2019
• Last Updated: January 7, 2019

Record last verified: 2019-01

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)