A Digital Antimicrobial Stewardship Smartphone Application to Combat AMR: the AB-assistant
AB-assistant
1 other identifier
interventional
1,080
4 countries
4
Brief Summary
Optimal prescribing of antimicrobials is becoming increasingly challenging because of the growing complexity of guidelines and constantly changing distribution of infectious pathogens. Prescribing antimicrobials appropriately according to local guidelines optimizes therapy for the individual patient and reduces the emergence of resistance. By adapting and evaluating a smartphone based app containing local guidelines we aim to study appropriate prescribing of antimicrobials by physicians in three hospitals (Netherlands, Sweden and Switzerland).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2020
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 3, 2019
CompletedFirst Posted
Study publicly available on registry
January 4, 2019
CompletedStudy Start
First participant enrolled
September 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2022
CompletedAugust 4, 2020
July 1, 2020
1 year
January 3, 2019
July 31, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Appropriate empirical antimicrobial therapy
According to predefined criteria
12 months
Secondary Outcomes (12)
Total prescription of antimicrobial drugs
12 months
Total prescription of antimicrobial drugs per AWaRe category in DDD/admission
12 months
Antimicrobial costs
12 months
Length of hospital stay (LOS)
12 months
In-hospital mortality
12 months
- +7 more secondary outcomes
Study Arms (2)
AB-assistant
EXPERIMENTALUse of the AB-assistant app by physicians in intervention wards.
Standard antimicrobial stewardship
NO INTERVENTIONPhysicians on these wards will use conventional ways to assess local guidelines to prescribe antimicrobials.
Interventions
The AB-assistant is an antimicrobial stewardship smartphone application that offers local antimicrobial guidelines to physicians currently assessed per website or paper/digital booklet.
Eligibility Criteria
You may qualify if:
- Cluster level (wards):
- Medical and surgical wards.
- Physician level:
- All physicians involved in antibiotic prescribing decisions in the participating wards.
- Patient level:
- All patients hospitalized in the participating wards \>= 18 years of age to whom systemic antimicrobials are prescribed.
You may not qualify if:
- Cluster level (wards):
- Outpatient clinics
- Psychiatry wards
- ICU
- Physician level:
- None
- Patient level:
- None
- Treatment level:
- Surgical and medical prophylaxis.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Annelies Verbonlead
- Erasmus Medical Centercollaborator
- University Hospital, Genevacollaborator
- Uppsala University Hospitalcollaborator
- University of Calgary Cumming School of Medicinecollaborator
Study Sites (4)
University of Calgary Cumming School of Medicine and Alberta Health Services, Department of Medicine
Calgary, Alberta, T2N 2TN, Canada
Erasmus Medical Center
Rotterdam, South Holland, 3015 CN, Netherlands
Uppsala University, Dept of Medical Sciences
Uppsala, 751 85, Sweden
Geneva University Hospitals
Geneva, Canton of Geneva, 1211, Switzerland
Related Publications (2)
Helou RI, Catho G, Faxen L, Hulscher M, Teerenstra S, Conly J, Huttner BD, Tangden T, Verbon A. Impact of a smartphone application for appropriate antibiotic prescribing at three tertiary hospitals: an international, multicentre stepped-wedge cluster randomized trial. Clin Microbiol Infect. 2025 Jul;31(7):1172-1179. doi: 10.1016/j.cmi.2025.02.026. Epub 2025 Mar 1.
PMID: 40032084DERIVEDHelou RI, Catho G, Peyravi Latif A, Mouton J, Hulscher M, Teerenstra S, Conly J, Huttner BD, Tangden T, Verbon A. Study protocol for an international, multicentre stepped-wedge cluster randomised trial to evaluate the impact of a digital antimicrobial stewardship smartphone application. BMJ Open. 2020 Jun 4;10(6):e033640. doi: 10.1136/bmjopen-2019-033640.
PMID: 32503867DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
B D Huttner, MD, MS
University Hospital, Geneva
- PRINCIPAL INVESTIGATOR
T Tängdén, MD, PhD
Uppsala University
- PRINCIPAL INVESTIGATOR
John Conly, Prof. Dr.
University of Calgary Cumming School of Medicine
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Masking Details
- Masking of care providers and investigators is not feasible. Outcome assessors and data analysts will be blinded to the study arm allocation.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Prof. dr.
Study Record Dates
First Submitted
January 3, 2019
First Posted
January 4, 2019
Study Start
September 1, 2020
Primary Completion
September 1, 2021
Study Completion
January 1, 2022
Last Updated
August 4, 2020
Record last verified: 2020-07
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, CSR
De-identified raw data will be made publicly on request available from the time of publication or within a reasonable time period of the experiments being completed. General project data and metadata will be included in the supplementary data of published articles if needed and or shared through university repositories.