Effect of Stimulant Drugs on Social Perception
ESP
1 other identifier
interventional
36
1 country
1
Brief Summary
The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA). The investigators seek to characterize the "uniquely social" effects of MDMA.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1 healthy
Started Jun 2016
Longer than P75 for phase_1 healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2018
CompletedFirst Submitted
Initial submission to the registry
November 30, 2018
CompletedFirst Posted
Study publicly available on registry
December 31, 2018
CompletedResults Posted
Study results publicly available
January 5, 2024
CompletedJanuary 5, 2024
March 1, 2023
2.2 years
November 30, 2018
June 14, 2022
March 29, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Responses to Affective Touch
Participants will complete an affective touch task during which time they will rate pleasantness of touch on a likert scale of 1-7, with higher scores indicating greater ratings of pleasantness
End of study (time 0 and approximately six weeks later)
Study Arms (4)
Placebo
PLACEBO COMPARATORSubjects will attend one session during which they will receive a placebo capsule.
Low dose MDMA
EXPERIMENTALSubjects will attend one session during which they will receive 0.75mg/kg MDMA.
High dose MDMA
EXPERIMENTALSubjects will attend one session during which they will receive 1.5mg/kg MDMA.
Methamphetamine
EXPERIMENTALSubjects will attend one session during which they will receive 20mg methamphetamine.
Interventions
Participants will be given 0.75mg/kg of 1.5mg/kg MDMA
Eligibility Criteria
You may qualify if:
- High school degree
- English fluency
- Healthy
- Has used MDMA
You may not qualify if:
- Pregnant or trying to become pregnant
- Any medical or psychiatry condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Chicago
Chicago, Illinois, 60637, United States
Related Publications (1)
Bershad AK, Hsu DT, de Wit H. MDMA enhances positive affective responses to social feedback. J Psychopharmacol. 2024 Mar;38(3):297-304. doi: 10.1177/02698811231224153. Epub 2024 Jan 27.
PMID: 38279662DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Harriet de Wit
- Organization
- University of Chicago
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 30, 2018
First Posted
December 31, 2018
Study Start
June 1, 2016
Primary Completion
August 1, 2018
Study Completion
August 1, 2018
Last Updated
January 5, 2024
Results First Posted
January 5, 2024
Record last verified: 2023-03