NCT03788655

Brief Summary

In this feasibility study (non-randomized), the applicability of a new "moving cell" biliary stents (by HILZO) in Klatskin tumors (bile duct obstruction) will be investigated. The HILZO Moving-Cell Stent to be examined here is a non-coated metal stent with a novelty. The meshes have a diameter of 4 mm, which is rather small compared to most other stents. This significantly increases the radial force and thus the stability of the stent. Furthermore, ingrowth by tumors in the stent is difficult. The special feature is that the individual meshes can easily be stretched to 10 mm without changing the stability of the stent. This allows a second stent to pass through the first to another segment of liver.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Dec 2018

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 25, 2018

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 27, 2018

Completed
4 days until next milestone

Study Start

First participant enrolled

December 31, 2018

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2020

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2021

Completed
Last Updated

December 27, 2018

Status Verified

December 1, 2018

Enrollment Period

1.9 years

First QC Date

December 25, 2018

Last Update Submit

December 25, 2018

Conditions

Keywords

metal stentbiliary stricturestenting

Outcome Measures

Primary Outcomes (1)

  • Technical feasibility of intrahepatic stenting

    Successful biliary drainage by new stent

    12 month

Secondary Outcomes (5)

  • Number of drained segments

    12

  • Length of intervention

    12 month

  • Stent dysfunction

    12 month

  • Number of necessary endoscopies per year

    12 month

  • Survival rate

    12 month

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with the indication for palliative stenting of the bile duct system due to non-operable Klatskin tumors type II-IV

You may qualify if:

  • Indication for the palliative metal-stent system for malignant stenosis due to biliary cancer (Klatskin tumor).

You may not qualify if:

  • Age under 18 years
  • Pregnancy
  • Contraindication to an endoscopic examination
  • Life expectancy under 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Klinikum der J. W. Goethe-Universität

Frankfurt am Main, 60590, Germany

RECRUITING

MeSH Terms

Conditions

Bile Duct Neoplasms

Condition Hierarchy (Ancestors)

Biliary Tract NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsBile Duct DiseasesBiliary Tract DiseasesDigestive System Diseases

Study Officials

  • Mireen Friedrich-Rust, Prof.

    University Clinic Frankfurt am Main

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mireen Friedrich-Rust, Prof.

CONTACT

Fabian Finkelmeier, Dr.

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Record Keeper, Clinical Professor

Study Record Dates

First Submitted

December 25, 2018

First Posted

December 27, 2018

Study Start

December 31, 2018

Primary Completion

December 1, 2020

Study Completion

June 1, 2021

Last Updated

December 27, 2018

Record last verified: 2018-12

Locations