The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation

NCT03788564 | Completed DMC

• 1 other identifier: 4-2017-0727
• Study Type: observational
• Target: 315
• Locations: 1 country
• Sites: 1

Brief Summary

The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval. Changes in the flow of ion currents could result from the genetic variation of myocardial ion channels by gene polymorphism. This study is to investigate the association of cardiac ion channel related gene polymorphism and prolonged QTc interval after endotracheal intubation in adult patients.

Conditions

Emergence Delirium

Outcome Measures

Primary Outcomes (1)

• QTc interval

  QTc interval prolongs followed by laryngoscopy due to changes in the autonomic nervous system. The restoration of the prolonged QTc could also be affected by the balance of autonomic nervous system or changes in the related cardiac ion channels.

  Before anesthesia, Before laryngoscopy, Right after laryngoscopy, 5 minutes after laryngoscopy

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

20-65 years old, scheduled for general anesthesia requiring direct laryngoscopy

You may qualify if:

• years old
• scheduled for general anesthesia requiring direct laryngoscopy

You may not qualify if:

• Patients taking antihypertensive medication (beta-blocker, CCB)
• patients taking other medications known to affect QTc interval
• Patients with abnormal ECG and prolonged QTc (\>500 msec)
• Diabetes, liver disease, kidney disease, heart failure, congenital heart disease
• Severe electrolyte imbalance
• illiterate, foreigners who cannot understand the consent form

Sponsors & Collaborators

• Yonsei University: lead

Study Sites (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, 120-752, South Korea

Location

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 25, 2018
• First Posted: December 27, 2018
• Study Start: September 24, 2017
• Primary Completion: May 3, 2020
• Study Completion: May 3, 2020
• Last Updated: September 29, 2020

Record last verified: 2020-09

Locations

KR (1)