Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

NCT03788330 | Completed

• 1 other identifier: XFGY001
• Study Type: interventional
• Target: 94
• Locations: 1 country
• Sites: 1

Brief Summary

A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

Conditions

Airway Morbidity; Cognitive and Attention Disorders and Disturbances; Oxidative Stress

Keywords

exhaled nitric oxide; Sick building syndrome; indoor air

Outcome Measures

Primary Outcomes (3)

• Exhaled nitric oxide

  Airway inflammation biomarker

  within 2 hours of the end of intervention in each week

• Oxidative stress biomarkers

  The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children.

  within 2 hours of the end of intervention in each week

• Sick building symdrom

  Answering questionnaire on sick biulding symdrom

  within 2 hours of the end of intervention in each week

Study Arms (3)

Fresh air system with filtration

EXPERIMENTAL

A fresh air ventilation system combined with PM2.5 filtration is applied in one primary school classroom.

Device: Fresh air system with filtration

Fresh air system with no filtration

PLACEBO COMPARATOR

A fresh air ventilation system with no PM2.5 filtration is applied in a parallel classroom.

Device: Fresh air system with filtration

Natural ventilation

NO INTERVENTION

Natural ventilation system was applied in the 3rd classroom as normal.

Interventions

Fresh air system with filtration DEVICE

Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms

Also known as: mechanical ventilation and filtration system

Fresh air system with filtration; Fresh air system with no filtration

Eligibility Criteria

• Age: 10 Years - 13 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• All invited primary school children in Grade 5 in an artibrarily selected school

You may not qualify if:

• Current airway symptoms (cough, airway infection, asthma et al.)
• Acute infectious diseases

Sponsors & Collaborators

• Fudan University: lead

Study Sites (1)

Fudan University

Shanghai, 200032, China

Location

MeSH Terms

Conditions

Cognition Disorders; Sick Building Syndrome

Interventions

Filtration; Respiration, Artificial

Condition Hierarchy (Ancestors)

Neurocognitive Disorders; Mental Disorders; Environmental Illness; Hypersensitivity; Immune System Diseases; Disorders of Environmental Origin

Intervention Hierarchy (Ancestors)

Chemistry Techniques, Analytical; Investigative Techniques; Physical Phenomena; Chemical Phenomena; Airway Management; Therapeutics; Resuscitation; Emergency Treatment; Respiratory Therapy

Study Officials

• Zhuohui Zhao, Dr

  Fudan University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Investigation director

Study Record Dates

• First Submitted: December 5, 2018
• First Posted: December 27, 2018
• Study Start: December 7, 2018
• Primary Completion: January 20, 2019
• Study Completion: January 22, 2019
• Last Updated: March 29, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)