NCT03780998

Brief Summary

New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
250

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2019

Shorter than P25 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 13, 2018

Completed
6 days until next milestone

First Posted

Study publicly available on registry

December 19, 2018

Completed
13 days until next milestone

Study Start

First participant enrolled

January 1, 2019

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2019

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2020

Completed
Last Updated

December 21, 2018

Status Verified

December 1, 2018

Enrollment Period

Same day

First QC Date

December 13, 2018

Last Update Submit

December 20, 2018

Conditions

Outcome Measures

Primary Outcomes (4)

  • Pain symtom differences

    Pain Scale from level 1 to level 10.

    six months

  • Lowering of the grade of the hemorroidal disease (hemoroidal disease is four grades; grade 1, grade 2, grade 3, and grade 4)

    Surgeon general physical examination

    six months

  • Closing of anal fissur line

    Surgeon general physical examination. Fissur line is exist or not exist

    six months

  • Lowering of leakage amount of perianal fistule

    Three grade: lower, same, more

    six months

Study Arms (5)

Group-1 (n: 50): Healthy cases

Control group

Drug: Life7

Group-2 (n:50): Grade 1 hemorroid

With perianal examination diagnosed of grade 1 hemorroidal disease

Drug: Life7

Group-3 (n:50): Grade 2 hemorroid

With perianal examination diagnosed of grade 2 hemorroidal disease

Drug: Life7

Group-4 (n:50): Anal fissure cases

With perianal examination diagnosed of anal fissure cases

Drug: Life7

Group-5 (n:50): Simple perianal fistula

With perianal examination diagnosed of uncomplicated, simple perianal fistula cases

Drug: Life7

Interventions

Life7DRUG

Life7 will used on the perianal skin with finger tips

Also known as: Life 7
Group-1 (n: 50): Healthy casesGroup-2 (n:50): Grade 1 hemorroidGroup-3 (n:50): Grade 2 hemorroidGroup-4 (n:50): Anal fissure casesGroup-5 (n:50): Simple perianal fistula

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Older than 18 years old cases

You may qualify if:

  • Grade 1 and 2 hemorroidal disease
  • Cronic anal fissura
  • Uncomplicated simple perianal fistula

You may not qualify if:

  • Any malign tumour
  • Cronic colorectal disases
  • Routine used of vasoactive medication

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Biospecimen

Retention: SAMPLES WITHOUT DNA

histopathological evaluation

MeSH Terms

Conditions

HemorrhoidsFissure in Ano

Condition Hierarchy (Ancestors)

Rectal DiseasesIntestinal DiseasesGastrointestinal DiseasesDigestive System DiseasesVascular DiseasesCardiovascular DiseasesAnus Diseases

Central Study Contacts

erhan aysan, MD Prof

CONTACT

Fikrettin Sahin, Prof

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD Prof

Study Record Dates

First Submitted

December 13, 2018

First Posted

December 19, 2018

Study Start

January 1, 2019

Primary Completion

January 1, 2019

Study Completion

January 1, 2020

Last Updated

December 21, 2018

Record last verified: 2018-12